Artificial Intelligence in ANOCA

Launched by UMC UTRECHT · Apr 23, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a condition called angina with no obstructed coronary artery (ANOCA), which affects many people, especially women, and can lead to a poor quality of life and increased medical costs. Usually, doctors focus on identifying blockages in the coronary arteries to diagnose angina, but in 40-70% of patients, no such blockages are found. This trial aims to improve the way doctors can diagnose and understand ANOCA by using advanced techniques, including artificial intelligence, to better analyze heart activity during tests.

To be eligible for this trial, participants should be experiencing chest discomfort at least twice a week, even after receiving treatment, and have had tests showing no significant blockages in their coronary arteries. Participants will undergo a specific heart function test, which involves monitoring heart activity closely to identify any problems that may not be easily seen. The goal is to enhance the accuracy of diagnosing ANOCA, which may lead to better treatment options for those affected. Importantly, participants will need to understand Dutch well enough to communicate effectively throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Clinical indication for comprehensive coronary function testing because of persisting chest discomfort at least 2 times per week despite current medical therapy.
• • 2. Absence of obstructive coronary artery disease with an indication for revascularization, documented by means of recent coronary computed tomography angiography (CCTA) or invasive coronary angiography (with invasive coronary pressure measurements if clinically indicated).
• • 3. Patient is willing and able to provide written informed consent.
• Exclusion Criteria:
• • 1. Absence of chest discomfort after initiation of medical therapy.
• • 2. Language barrier preventing sufficient understanding and communication in Dutch.