LINC01844 as a Diagnostic Biomarker for POCD in Elderly Patients

Launched by SHANGHAI ZHONGSHAN HOSPITAL · Apr 25, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a potential new way to help diagnose Postoperative Cognitive Dysfunction (POCD) in older patients after surgery. POCD can cause memory problems and confusion following surgery, which can lead to more serious health issues. The researchers want to see if measuring a specific marker in the blood called LINC01844 can help identify patients who may develop POCD after undergoing elective lumbar surgery.

To participate in the study, you need to be between 65 and 85 years old and scheduled for a specific type of back surgery. You should be in generally good health but may have some underlying health conditions. If you join, you will have memory and thinking tests before your surgery and on the first, third, and fifth days after surgery. At the same times, your blood will be tested to check the levels of LINC01844. This study may help improve the way doctors understand and diagnose cognitive issues in older patients after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients scheduled to perform elective lumbar decompression and interbody fusion under general anesthesia;
• • 65-85 years old;
• • American Society of Anesthesiologists (ASA) physical status I-III level;
• • Body mass index (BMI) between 20 Kg/m2 and 28 Kg/m2;
• • From whom written informed consent is obtainable either from the patient or from a legal representative;
• Exclusion Criteria:
• • Patents with cognitive dysfunction preoperatively;
• • Patents with verbal, visual and auditory defects;
• • Patients with history of alcohol and/or drug abuse, or history of neurological and psychotic disorders;
• • Patients with history of hospital admission and therapy within 30 days.