THRIVE Study: Positive Affect Training for Endocrine Therapy Medication Adherence

Launched by JOANNA ARCH · Apr 24, 2024

Keywords

ClinConnect Summary

The THRIVE Study is looking to help women who have been treated for hormone receptor-positive breast cancer by improving their feelings about taking anti-hormonal medication, which is important for preventing cancer from returning. This study will test an online program that teaches Positive Affect Training (PAT), a method designed to boost positive emotions and reduce negative feelings about taking medication. The goal is to make it easier for women who have completed their primary cancer treatment to stick to their prescribed endocrine therapy.

To participate in this study, women aged 70 and older who have finished their main treatment and are currently on or have been prescribed endocrine therapy within the last two years may be eligible. Participants need to express some difficulty or concern about taking their medication and should have internet access to complete online assessments. If chosen, they will take part in a supportive online program and share their experiences to help improve this approach for future patients. It's important to note that women with advanced cancer or those who have difficulty using the technology won't be eligible for this study.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • hormone receptor-positive breast cancer stages 0-3
• • have finished primary treatment (chemotherapy/radiation/surgery)
• • are prescribed endocrine therapy (ET) currently or within the last two years
• * score above specified cut off (range, 0-10) on any of three questions:
• • 1. How upset are you by having to take anti-hormonal therapy
• • 2. How bothered are you by the side effects?
• • 3. How difficult is it for you to take your anti-hormonal medication every day?
• • have internet access to complete online assessments and intervention components or agree to use and return a study wifi-activated iPad.
• Exclusion Criteria:
• • metastatic disease
• • Individuals who are unable to interact with the intervention as needed. This includes those who are extremely visually impaired to the degree that they cannot see the screen and interact as required and individuals who cannot read and/or write in English. This is due to the nature of the intervention itself. If a participant is unable to interact with THRIVE as required, they are unlikely to benefit from the intervention or offer insightful feedback that can be used in refining the program.