Inflammatory Resolution in Cardiometabolic Health and Disease

Launched by UNIVERSITY OF AARHUS · Apr 25, 2024

Keywords

ClinConnect Summary

This clinical trial, called "Inflammatory Resolution in Cardiometabolic Health and Disease," is investigating how inflammation affects people with different body weights, including those who are lean, overweight, or obese. Researchers want to understand why some people can manage inflammation better than others and explore the potential benefits of certain natural compounds called pro-resolving lipids that may help reduce inflammation. They are looking for volunteers aged 18 and older who have a body mass index (BMI) greater than 18.5, whether they are healthy or have health issues related to weight.

If you decide to participate, you'll need to provide informed consent, which means you'll agree to take part after understanding what the study involves. Participants will undergo tests to measure their inflammation levels, and you should be prepared for a fasted blood draw. However, there are certain conditions that may exclude you from the study, such as taking specific medications that affect inflammation or having chronic health issues. This study aims to improve our understanding of inflammation and help find new treatments for obesity and heart-related diseases.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Informed signed consent has been obtained from the volunteer.
• • The volunteer has a BMI greater than 18.5 kg/m2
• • Men and women over the age of 18 are included.
• Exclusion Criteria:
• • The study staff contacting a potential participant perceives that the individual has difficulty understanding the information.
• • An MD determines that the individual is on too many medications to participate.
• • The individual takes a medication that is approved by the MD, but he/she is not willing or not able to wait with any potential morning medication until after their fasted blood-draw.
• • The individual states that they have increased bleeding tendency or are using anti-coagulant (blood thinning) medication.
• • The individual has some form of chronic inflammation.
• • The individual regularly uses medication that affects inflammatory resolution (e.g., low-dose aspirin).
• • The individual uses immunosuppressive drugs (e.g., methotrexate).
• • The individual regularly consumes fish oils (omega 3).
• • The individual has significant gastrointestinal problems.
• • The individual smokes or uses chewing tobacco.
• • The individual has been drinking alcohol two days before the study visit.
• • The individual has tattoos or body piercings on the forearms and / or the stomach that can affect the examination.
• • The individual does not follow instructions given in the research study.