Deep-sea Fish Oil for Prevention of Acute Radiation-induced Esophagitis

Launched by FIRST AFFILIATED HOSPITAL OF CHENGDU MEDICAL COLLEGE · Apr 29, 2024

Keywords

ClinConnect Summary

This clinical trial is researching whether deep-sea fish oil can help prevent a condition called acute radiation-induced esophagitis (ARIE) in patients receiving radiation treatment for esophageal cancer. ARIE can cause pain and discomfort in the esophagus, which is the tube connecting your throat to your stomach. In this study, 120 participants will be divided into two groups: one group will receive 1 gram of deep-sea fish oil twice a day, while the other group will not receive any treatment. Researchers will monitor how effective the fish oil is in reducing the occurrence and severity of ARIE, as well as checking for any side effects or changes in health during the trial.

To be eligible for this trial, participants must be between 18 and 70 years old and diagnosed with esophageal, lung, or breast cancer. They should also be able to tolerate radiation therapy and have no serious issues with their liver, kidneys, or heart that would prevent them from participating. If you decide to join, you will need to provide informed consent, meaning you understand the study and agree to participate. Throughout the trial, your health will be closely monitored to ensure your safety. This is a great opportunity to contribute to research that could improve the care of future patients undergoing radiation therapy.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years old, ≤70 years old, gender is not limited;
• • 2. Histological or cytological evidence of esophageal, lung, or breast cancer;
• • 3. ECOG score of 0-2, no swallowing pain or severe dysphagia before radiotherapy;
• • 4. Liver and kidney function, bone marrow function and cardiopulmonary function are not contraindicated by radiotherapy and chemotherapy;
• • 5. PG-SGA score \<9;
• • 6. Not pregnant or breastfeeding;
• • 7. The subject must understand and sign the informed consent
• • 8. Have reading comprehension ability and can complete the questionnaire with medical assistance;
• • 9. Those who voluntarily participate in the study and sign the informed consent letter in person.
• Exclusion Criteria:
• • 1. Prior radiation therapy;
• • 2. Patients with severe underlying diseases, who cannot tolerate radiotherapy and chemotherapy due to severe liver and kidney insufficiency and poor cardiopulmonary function;
• • 3. Pregnant or lactating female patients;
• • 4. Suffering from severe mental illness and poor compliance;
• • 5. Other cases deemed unsuitable for inclusion by the researchers.