A Study to Find the Best Dose of HS-10384 to Treat Vasomotor Symptoms in Postmenopausal Women

Launched by HANSOH BIOMEDICAL R&D COMPANY · Apr 27, 2024

Keywords

ClinConnect Summary

The clinical trial, titled "A Study to Find the Best Dose of HS-10384 to Treat Vasomotor Symptoms in Postmenopausal Women," is designed to investigate how effective and safe a new treatment called HS-10384 is for women who are experiencing bothersome hot flashes and night sweats, known as vasomotor symptoms. This study will specifically involve women aged between 40 and 65 years who have been through menopause and are experiencing a significant number of these symptoms each week.

Eligible participants will need to have at least 50 moderate to severe symptoms per week, and they must not have certain health issues that could complicate their participation. This includes conditions like uncontrolled high blood pressure or a history of certain tumors. Participants will be randomly assigned to receive either the study medication or a placebo (a treatment that does not contain the active drug), and they will not know which one they are receiving. Throughout the trial, they will keep a diary to track their symptoms. This study is not yet recruiting participants, but it aims to help improve treatment options for women dealing with uncomfortable menopausal symptoms in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Women between 40 and 65 years old (including extremes);
• • 2. The body mass index at screening is between 18.5\~30 kg/m2 (including extremes)；
• • 3. Subjects are postmenopausal women at screening as qualified by any of the following criteria: spontaneous amenorrhea ≥ 12 months, or spontaneous amenorrhea ≥ 6 months and FSH\>40 IU/L (without other obvious pathological or physiological reasonsbefore screening), or documented surgical sterilization (such as hysterectomy, bilateral salpingectomy or bilateral oophorectomy, etc.);
• • 4. At least 50 moderate to severe vasomotor symptoms per week (ie, 7 consecutive days), or 7 moderate to severe vasomotor symptoms per day (ie, 7 consecutive days) recorded in the daily diary during the screening period;
• • 5. The blood pregnancy test of female subjects at baseline period is negative.
• Exclusion Criteria:
• • 1. Participants with disease history of unexplained uterine bleeding, endometrial hyperplasia, ovarian tumor, pituitary tumor, or other diseases evaluated by the principal investigator as not suitable for this study;
• • 2. Have a history of migraine within 3 months before screening;
• • 3. Uncontrolled hypertension and a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg;
• • 4. Previous or current history of a malignant tumor, except for basal cell carcinoma;
• • 5. Participants with clinically significant diseases (such as neuropsychiatric system, cardiovascular system, urinary system, digestive system, respiratory system, skeletal muscle system, endocrine and metabolic system, blood system, skin disease, immune system, tumor, etc.) were evaluated by the researcher as not suitable for this study;
• • 6. Within 4 weeks or 5 half-lives (whichever is longer) before taking drug, participants have taken hormonal treatment, hormonal contraceptive or other therapy due to VMS;
• • 7. Within 4 weeks or 5 half-lives (whichever is longer) before screening, and during the whole study period, it is expected to take any medicine and health care products, including prescription drugs, immunomodulator or Chinese herbal medicine, etc.;
• • 8. Participants have participated in any interventional study or taken study drugs within 3 months before screening;
• • 9. Judged by the Investigator to be unsuited to participate in the study based on findings observed during physical examination, vital sign assessment, or 12-lead electrocardiogram (ECG), et al.;
• • 10. Active liver disease or jaundice, or values of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2.5 x the upper limit of normal (ULN); or total bilirubin or direct bilirubin \>1.5 x ULN;
• • 11. Creatinine \>1.5 x ULN; or estimated glomerular filtration rate (eGFR) using the CKD-EPI formula ≤59 mL/min/1.73 sqm at the screening visit;