Ocular Perfusion in Patients With Unilateral Carotid Artery Stenosis

Launched by MEDICAL UNIVERSITY OF VIENNA · May 2, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how blood flows to the eyes in patients who have a narrowing of the carotid artery, which can affect blood supply to the brain. Researchers want to see how this blood flow changes before and after certain procedures called carotid endarterectomy or carotid artery stenting, which are done to improve blood flow. They will also compare the eye blood flow of these patients with healthy individuals of similar age and gender. Additionally, the study will measure oxygen levels in the brain during these procedures to understand more about how carotid artery stenosis affects overall health.

To participate in this trial, you must be at least 18 years old and have been diagnosed with unilateral carotid artery stenosis, meaning only one side of your carotid artery is narrowed. You will also need to have normal eye health, unless any issues are considered minor. Healthy individuals who wish to participate must also be 18 or older, have normal eye health, and be non-smokers. Throughout the study, participants can expect to undergo various tests related to eye and brain health. If you have certain medical conditions or have recently experienced other health issues, you may not be eligible to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for patients with unilateral carotid artery stenosis:
• • Men and Women aged ≥ 18 years
• • Signed informed consent
• • Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant
• • Diagnosis of unilateral carotid artery stenosis and scheduled carotid endarterectomy or carotid artery stenting
• Inclusion criteria for healthy age- and sex-matched control subjects:
• • Men and Women aged ≥ 18 years
• • Signed informed consent
• • Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant
• • Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant
• • Non-Smokers
• Exclusion criteria for patients with carotid artery stenosis and healthy age- and sex-matched control subjects:
• • Blood donation in the three weeks preceding the study
• • Symptoms of a clinically relevant illness in the three weeks preceding the study
• • Ocular inflammation or infection within the last 3 months
• • History of family history of epilepsy
• • Diabetes mellitus type 1 or type 2
• • Pregnant or breast-feeding women
• • Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception