Surgical Prehabilitation on Autonomic Nervous System (TUNE)

Launched by UNIVERSITÀ VITA-SALUTE SAN RAFFAELE · Apr 30, 2024

Keywords

ClinConnect Summary

The TUNE trial is studying how a special program called "prehabilitation" can help patients prepare for major thoracic surgery, such as lung procedures, by improving their heart health before the operation. Heart rate variability (HRV) is a measure of how well the heart can respond to stress, and this study aims to see if taking part in the prehabilitation program can make a difference in HRV and also reduce the time patients spend in the hospital after their surgery.

To qualify for the trial, participants must be at least 18 years old and scheduled for specific types of thoracic surgery. They cannot have certain serious heart or other medical conditions that could make it unsafe for them to participate. Those who join the study will be randomly assigned to either the prehabilitation program or to receive standard care before their surgery. The trial is currently recruiting, and all eligible patients are encouraged to consider participating to help improve care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients scheduled to undergo major thoracic surgery including lobectomy, bilobectomy, anatomical segmentectomy, and pneumonectomy with general anesthesia;
• • Patients ≥18 years of age at the time of randomization;
• • Patients who provide written informed consent to participate.
• Exclusion Criteria:
• • New York Heart Association classes 3-4;
• • End-stage organ dysfunction;
• • American Society of Anesthesiologists physical status classes 4-5;
• • Disabling orthopedic, neuromuscular, and psychiatric diseases;
• • Other medical conditions that preclude safe training.
• • Atrial fibrillation or other arrhythmia (e.g. bigeminy, trigeminy) that preclude heart rate variability analysis.
• • Unable to provide written informed consent to participate