Impact of Exercise Intensity on Fitness, Extracellular Vesicles, Inflammation, and Metabolism

Launched by UNIVERSITY OF BRITISH COLUMBIA · May 1, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different levels of exercise intensity during indoor cycling can affect health and fitness. Participants will undergo a cycling test to measure their fitness levels before and after a 6-week training program. There are three groups in the study: one group will cycle at a moderate pace, another at a slightly harder pace, and the third group will not change their usual activities. Blood samples will be taken to check for changes in health markers related to inflammation and metabolism.

To join the study, you need to be a healthy adult between 18 and 40 years old, with a normal body weight. You should also be getting some exercise already, but you shouldn't have any serious health conditions like diabetes or heart disease. During the study, participants will ride a bike three times a week, with specific calorie-burning goals. After the study, participants will receive feedback on their fitness and blood test results if they are interested. This research aims to help people understand how different types of exercise can improve their health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Are between the ages of 18 and 40 years old.
• • Have a body mass index (BMI) between 18.5 and 30 kg/m\^2.
• • Perform between 60 and 200 minutes of aerobic physical activity per week.
• • Do not have a history of cardiovascular disease or diabetes.
• Exclusion Criteria:
• • Require immunomodulatory medication to treat an auto-immune disease, or rely heavily on over the counter anti-inflammatory medications (e.g., Advil).
• • Have a metabolic condition such as diabetes.
• • Have hypertension (blood pressure \> 160/90 mmHg).
• • Are uncomfortable with blood sampling.
• • Are an elite endurance athlete, or training specifically for an endurance event (\>3 structured aerobic training sessions, or \>150 min of specific aerobic-based/endurance training per week).
• • Adhere to an extreme diet (e.g., ketogenic diet, time restricted feeding).
• • Smoke cigarettes