Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort

Launched by PEKING UNIVERSITY FIRST HOSPITAL · May 1, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how two medications, dexmedetomidine and esketamine, can help reduce discomfort caused by urinary catheters in patients waking up from surgery. Many patients experience bladder discomfort after procedures that involve a urinary catheter, and the researchers want to find out if using these medications during anesthesia can help lessen this issue. The trial is specifically looking at patients who are scheduled for certain types of bladder or prostate surgeries and will need to have a urinary catheter after their operation.

To participate in the trial, you must be at least 18 years old and scheduled for a specific urological surgery under general anesthesia. You also need to be okay with having a urinary catheter after surgery. However, there are some health conditions that may prevent you from joining, such as severe heart problems or certain neurological disorders. If you decide to participate, you will help researchers learn more about how these medications can improve comfort after surgery, which could lead to better care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18 years or above;
• • Scheduled to undergo transurethral bladder or prostate surgery (including transurethral resection of bladder tumor, transurethral resection of prostate, and transurethral thulium laser prostatectomy) under general anesthesia;
• • Required postoperative retention of a three-chamber urinary catheter.
• Exclusion Criteria:
• • Indwelling urinary catheters or chronic analgesic therapy for ≥1 month before surgery;
• • Uncontrolled hypertension before surgery (resting ward systolic pressure \>180 mmHg or diastolic pressure \>110 mmHg);
• • Severe bradycardia (heart rate ≤50 beats per minute), sick sinus syndrome, or atrioventricular block of degree II or above without pacemaker, or having myocardial infarction, severe heart insufficiency (New York Heart Association class ≥3), or tachyarrhythmia within a year;
• • Preoperative history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;
• • Preoperative history of hyperthyroidism and pheochromocytoma;
• • Inability to communicate due to coma, severe dementia, or language barrier before surgery;
• • Severe liver dysfunction (Child-Pugh grade C), severe renal dysfunction (receiving dialysis before surgery), or Amercian Society of Anesthesiologists classification ≥IV;
• • Scheduled admission to the intensive care unit with endotracheal intubation after surgery;
• • Other conditions that are considered unsuitable for study participation.