Electrolyte Balance Effects of Sterofundin Versus Normal Saline in Diabetic Ketoacidosis

Launched by UNIVERSITI SAINS MALAYSIA · Apr 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different fluids, Sterofundin and Normal Saline, on patients with Diabetic Ketoacidosis (DKA), a serious condition that can occur in people with diabetes. The main goal is to see which fluid helps balance important electrolytes, like sodium and potassium, better over the first 24 hours in the Intensive Care Unit (ICU). Researchers want to find out if there’s a difference in how quickly patients’ bicarbonate levels improve and how sodium and potassium levels change after receiving either fluid.

To participate in this study, patients must be at least 18 years old and have been diagnosed with DKA. They should also be admitted to the ICU within 12 hours after starting initial treatment. However, patients with certain conditions, such as severe kidney failure or heart failure, or those who have already been treated with sodium bicarbonate before coming to the ICU, cannot join. If you are eligible and choose to participate, you will be randomly assigned to receive either Sterofundin or Normal Saline as your main treatment for the first day in the ICU. This trial is currently recruiting participants, and it aims to improve care for patients with DKA by understanding which fluid works better for electrolyte balance.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • DKA.
• • Aged ≥ 18 years old.
• • Patients admitted to ICU \< 12 hours after initial fluid resuscitation from emergency department/ ward.
• Exclusion Criteria:
• • End stage renal failure
• • Heart failure
• • Started treatment of sodium bicarbonate infusion prior to ICU admission
• • Known allergy to Sterofundin