CytoHealth - A Study of the Inflammatory Response to Exercise

Launched by YORK TEACHING HOSPITALS NHS FOUNDATION TRUST · May 1, 2024

Keywords

ClinConnect Summary

The CytoHealth trial is studying how the immune system responds to a short, intense exercise test in healthy volunteers. The researchers want to measure specific proteins in the blood, called cytokines and chemokines, which can reveal how the body reacts to the stress of hard exercise. This is important because understanding these responses could help improve care for cancer patients who need to undergo surgery. Better fitness is known to enhance recovery after major operations, and this study aims to gather information that can be compared to future studies involving cancer patients.

To participate in this study, individuals must be between the ages of 18 and 60 and able to give consent to join. Participants will undergo a blood test before and after completing a cycling exercise test at a university lab. It’s important to note that individuals with certain health conditions, recent illnesses, or who are pregnant will not be eligible to participate. Overall, this research seeks to improve our understanding of how exercise affects the immune system, which could ultimately benefit patients facing surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Any individual between the ages of 18 and 60 who has appropriately consented to take part in the study and who does not fulfil any of the 10 exclusion criteria.
• Exclusion Criteria:
• • 1. Individuals aged less than 18 years or over 60 years.
• • 2. Individuals who refuse or are unable to give informed consent
• • 3. Individuals with an impairment, injury or disability that prevents them from pedalling on a static bicycle.
• • 4. Individuals who are deemed by a clinician to be classified on the American Society of Anesthesiologists Physical Status Classification System (ASA) as ASA III or ASA IV.
• • 5. Individuals who have had an acute infective or inflammatory illness in the last 7 days.
• • 6. Individuals who have undertaken moderate or high intensity exercise in the 24 hours prior to the exercise testing.
• • 7. Individuals who have a cardiac or respiratory condition which poses significant restrictions on their exercise capacity, as assessed by a clinician. Including but not limited to the following: recent myocardial infarction, acquired or inherited arrythmias or cardiomyopathies, presence of an implantable defibrillator or pacemaker, uncontrolled or severe COPD, uncontrolled asthma, pulmonary hypertension, pulmonary fibrosis.
• • 8. Individuals who are pregnant.
• • 9. Individuals who are known to have an active malignancy or have undergone treatment for cancer in the last year.
• • 10. Individuals who are currently an inpatient in a hospital.