Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia

Launched by RUIJIN HOSPITAL · May 1, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how brain activity changes as patients wake up from general anesthesia during deep brain stimulation (DBS) surgery. Researchers want to understand the relationship between signals from deep brain areas and the activity in the outer layer of the brain, known as the cortex, to learn more about how consciousness returns after anesthesia.

To participate in this trial, you need to be between 18 and 75 years old and qualify for DBS surgery. You should also be able to understand and communicate well. However, if you have significant cognitive issues, severe depression, major organ problems, or certain other conditions, you may not be eligible. If you choose to join, you will have your brain activity monitored while you recover from anesthesia, which will help researchers gather important information about the recovery process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-75 years old
• • ASA (American Society of Anesthesiologists) classification I-III
• • Those who meet the indications for DBS surgery
• • Right-handed with normal listening and speaking abilities
• • The patient signs the informed consent form and cooperates with the researchers
• Exclusion Criteria:
• • Patients with cognitive impairment \[Montreal Cognitive Assessment (MoCA) score less than 26 points\];
• • Patients with severe depression \[Beck Depression Inventory (BDI-II) score greater than or equal to 25 points\];
• • Patients with important organs dysfunction, such as heart, lungs, liver, and kidneys; or patients with unstable vital signs;
• • Patients who are expected to enter the ICU after surgery;
• • Patients who are alcoholic, alcohol dependent or drug dependent;
• • Patients who have received general anesthesia one month before surgery, patients who are known to be allergic to general anesthetics;
• • The DBS surgery exceeds 4 hours;
• • Patients who are pregnant.