The Effect of Pregabalin and Etoricoxib on Pain Alone Versus in Combination

Launched by MUHAMMAD ILYAS · May 2, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how effective a combination of two medications, pregabalin and etoricoxib, is in reducing pain and improving daily activities for people suffering from chronic low back pain that comes from nerve issues. The researchers believe that taking both medications together will work better than taking just etoricoxib alone. The study will involve 140 participants aged 20 to 65, who have been experiencing chronic low back pain for at least six months. To participate, individuals should not have had any prior back surgeries or taken certain medications that could interfere with the study.

Participants in the study will be divided into two groups. One group will take etoricoxib alone for the first four weeks, while the other group will take it along with pregabalin during the second phase of the trial. Throughout the study, participants will have their pain levels measured and will answer questions about how their back pain affects their daily life. It’s important to note that the trial is not yet recruiting participants, so interested individuals will need to wait for further announcements about enrollment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants within age 20-65 years
• • Both male and non-pregnant non-lactating female patients will be included in the study
• • Patients experiencing CLBP symptoms from last 6 months
• Exclusion Criteria:
• • • Patients with the history of antidepressant, opioid, and benzodiazepine medications
• • Patients with the history of CYP1A2 inhibitors usage
• • Patients already taking pregabalin
• • Patients with the history of suicidal ideation, severe depression, anxiety disorder psychosis, and cognitive impairment