Age Related Differences in Respiratory Immune Responses in Influenza Virus Infection
Launched by KAROLINSKA INSTITUTET · May 4, 2024
Trial Information
Current as of July 21, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
This observational study will specifically investigate different immunological parameters in blood and at the site of infection in patients with IAV symptoms or confirmed infection to understand parameters related to disease course. Blood and airway samples will be analyzed for immune cell subsets and their functionality, antibodies and other soluble mediators and linked to clinical data. Immune cells will be analyzed using multi-color flow cytometry, RNA sequencing, and in vitro functionality assays. Fluids (plasma, serum, supernatants from airway samples and cell culture supernatants) wil...
Gender
ALL
Eligibility criteria
- Inclusion Criteria Patients:
- • Influenza A like symptoms and/or
- • Confirmed airway infection
- Exclusion Criteria Patients:
- • Current malignancies
- • Immunosuppressive treatment, not including/except hydrocortisone
- Exclusion Criteria Controls:
- • Airway infection within the past four weeks
- • Ongoing antibiotic treatment
- • Immunosuppressive treatment
About Karolinska Institutet
Karolinska Institutet is a renowned medical university located in Sweden, recognized for its commitment to advancing healthcare through innovative research and education. As a leading sponsor of clinical trials, the institution focuses on translating scientific discoveries into effective treatments and therapies, emphasizing patient-centered approaches. With a strong emphasis on collaboration and interdisciplinary research, Karolinska Institutet plays a pivotal role in addressing global health challenges and improving patient outcomes, leveraging its extensive network of experts and state-of-the-art facilities to drive clinical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Stockholm, , Sweden
Södertälje, , Sweden
Stockholm, , Sweden
Stockholm, , Sweden
Stockholm, , Sweden
Patients applied
Trial Officials
Anna Smed Sörensen, PhD
Principal Investigator
Karolinska Institutet
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported