Investigating Near-Threshold Perception During Anesthetic Sedation

Launched by UNIVERSITY OF MICHIGAN · May 3, 2024

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ClinConnect Summary

This clinical trial is looking to understand how our minds work during different levels of anesthesia, specifically when using a medication called propofol, which is commonly used to help people relax before surgery. The researchers also want to see if a special technique called ultrasonic brain stimulation can help people wake up faster after being sedated.

To participate in this study, you need to be a healthy adult aged between 18 and 65, right-handed, and with a body mass index (BMI) of less than 30. You should speak English and not have any conditions that would make it unsafe for you to undergo an MRI scan, which is a type of imaging test used in the study. If you join, you can expect to receive propofol while your brain activity is monitored, helping researchers learn more about how anesthesia affects consciousness. It's important to know that participants must avoid alcohol for 24 hours before the study and that certain medical histories, like severe allergies, or specific tattoos, may prevent someone from joining.

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Eligibility criteria

• Inclusion Criteria:
• • Healthy study subjects with American Society of Anesthesiologists (ASA)-1 status.
• • Right-handed
• • Body mass index (BMI) less than 30.
• • All subjects will be English speakers.
• Exclusion Criteria:
• • Medical contraindication to magnetic resonance imaging (MRI) scanning; are unable to undergo MRI scanning because of possible pregnancy or currently breastfeeding, BMI\>30, metallic substances in the body, claustrophobia, anxiety, or cardiopulmonary disease; or have an intracranial structural abnormality on T1-weighted MRI scans.
• • History of allergy to propofol, eggs or egg products, soybean or soybean products, neurological, cardiovascular, or pulmonary illness; significant head injury with loss of consciousness; learning disability or other developmental disorder; sleep apnea or any severe snoring history; gastroesophageal reflux disease (GERD) or heartburn; pancreatitis or a history of pancreatitis, or sensory/motor loss sufficient to interfere with performance of the study.
• • Tattoos in the head or neck region will be excluded from study; other tattoos are subject to determination by investigators based on their assessment regarding participant safety. To eliminate aspiration risk subjects will also be excluded if they have had recent food or liquid intake (within 8 hours).
• • History of drug use, have a positive drug screen, are unwilling to abstain from alcohol for 24 hours prior to dosing, or have a current history of nicotine use.
• • Pregnancy