Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate

Launched by UNIVERSITY HOSPITAL BISPEBJERG AND FREDERIKSBERG · May 5, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to understand if doctors can identify patients at risk of developing blood clots that could lead to a stroke, particularly in those with a heart condition called atrial fibrillation. During the trial, patients who have agreed to participate will undergo a common procedure where a small pouch in the heart, known as the auricle, is closed off. This is done to help protect the brain from stroke. Along with this procedure, researchers will collect and analyze blood and tissue samples from the auricle, as well as examine the heart's electrical activity using an electrocardiogram (ECG) before the surgery.

To join the trial, participants need to be between the ages of 65 and 74 and must be scheduled for open-heart surgery, such as bypass surgery or valve repair. They also need to provide their consent to participate. Importantly, people currently dealing with heart infections or those who may not be able to follow up after the trial will not be eligible. Participants can expect to contribute to important research that may help doctors better understand stroke risks in future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • signed informed consent AND
• * planned any open-heart surgery:
• • CABG
• • valve repair or replacement
• • aorta surgery
• • any combination of the above
• Exclusion Criteria:
• • current endocarditis
• • follow-up not possible