Salivary Conductivity Screening for Dry Eye Disease and Sjögren's Syndrome

Launched by CHANG GUNG MEMORIAL HOSPITAL · May 6, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help diagnose primary Sjögren's syndrome, a condition that can cause dry eyes and mouth. Researchers want to see if measuring the conductivity of saliva—how easily electricity flows through it—combined with tests for the surface of the eye can provide a simple and non-invasive method to identify this autoimmune disease. This is important because Sjögren's syndrome is often a cause of dry eye disease, which can lead to uncomfortable symptoms like a gritty feeling in the eyes, redness, and blurred vision.

To participate in this trial, you need to be an adult aged 20 or older and either have normal tear production or suffer from dry eye syndrome. However, certain medical conditions and recent treatments, such as some infections and autoimmune diseases, may exclude you from joining. If you decide to participate, you can expect a straightforward process involving saliva and eye tests without the need for invasive procedures. This trial aims to improve how we diagnose Sjögren's syndrome, potentially leading to better care for those affected by dry eye disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adults aged 20 and older
• • 2. Patients with normal and dry eye syndrome
• Exclusion Criteria:
• • 1. Hepatitis C
• • 2. Acquired immunodeficiency syndrome
• • 3. Lymphoma
• • 4. Intestinal amyloidosis
• • 5. Open pulmonary tuberculosis
• • 6. Graft-versus-host disease
• • 7. Rheumatoid or lupus erythematosus and other autoimmune diseases
• • 8. IgG4-related diseases
• • 9. Head and neck radiation therapy
• • 10. Glaucoma
• • 11. History of infectious keratitis
• • 12. History of ophthalmic surgery
• • 13. Wear contact lenses in the month before the trial
• • 14. Chew betel nuts or smoke within one month before the trial