Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study

Launched by TONGJI HOSPITAL · May 7, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a medication called oliceridine to see how well it can manage pain after surgery while reducing side effects. The main goal is to find the lowest dose of oliceridine that provides quick pain relief for patients recovering from laparoscopic upper abdominal surgery. Researchers will also look at how oliceridine affects recovery in areas like breathing, digestion, nausea, thinking abilities, and emotional well-being. Additionally, this study is unique because it uses advanced techniques to understand how oliceridine works at a molecular level to support faster recovery.

To participate in this trial, individuals should be between 18 and 70 years old, be scheduled for a laparoscopic surgery that lasts no longer than 4 hours, and be willing to receive pain relief through an intravenous method after surgery. They should also be in generally good health, without certain medical conditions or a history of substance abuse. Participants can expect close monitoring during their recovery as researchers gather information to improve pain management strategies in future surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. ASA grades 1-2
• • 2. Age \> 18 years and \< 70 years
• • 3. Laparoscopic upper abdominal surgery under general anesthesia is planned, and the operation time is not more than 4 hours
• • 4. Voluntarily receive postoperative controlled intravenous analgesia
• • 5. Subjects understand and can cooperate with this study
• • 6. Subjects can provide and sign written informed consent prior to conducting investigation-related screening procedures
• Exclusion Criteria:
• • 1. BMI\>30 kg/m2 or \< 19 kg/m2
• • 2. Patients with preoperative use of opioids, acute and chronic pain or hyperalgesia
• • 3. Patients with coronary atherosclerotic heart disease, significant ischemic heart disease, severe angina, heart failure, valvular disease or other heart disease
• • 4. More severe hepatic and renal insufficiency
• • 5. A history of mental illness or alcoholism
• • 6. A history of alcohol or drug abuse
• • 7. Combined with cranial pressure, intraocular pressure or glaucoma
• • 8. Poorly controlled or untreated hypertension before surgery
• • 9. Preeclampsia or eclampsia
• • 10. Untreated and undertreated hyperthyroidism
• • 11. Combined with autoimmune disease
• • 12. Unable to use the numerical rating scale
• • 13. History of chronic cough
• • 14. Surgery is expected to take more than 4 hours Patients enrolled in other clinical trials within 3 months