Mood and Decision-making in Methamphetamine Use Disorder

Launched by LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC. · May 8, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Mood and Decision-making in Methamphetamine Use Disorder," is studying how our feelings and memories can affect decision-making in people who have struggled with methamphetamine use. Researchers want to see if recalling positive memories can help improve mood and decision-making skills in individuals with methamphetamine use disorder (MUD). They will compare two groups: one group will recall positive memories, while the other group will not. The study aims to understand if this memory recall can help reduce negative feelings and improve brain activity related to decision-making.

To participate, individuals must be between 18 and 65 years old, speak English, and have been diagnosed with methamphetamine use disorder in the past year. They should also be actively receiving treatment for substance use. Participants will engage in tasks that test their decision-making abilities before and after the memory recall exercise. Throughout the study, participants will have their experiences monitored closely, ensuring a safe environment. This research could provide valuable insights into new ways to support recovery from methamphetamine use disorder.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults 18-65 years old
• • English proficiency as evaluated by language ability during screening
• • Past-year diagnosis of DSM-5 methamphetamine use disorder (MUD) confirmed by the MINI
• • Actively enrolled in treatment for substance use disorder.
• Exclusion Criteria:
• • Severe traumatic brain injury (as indicated by a score ≥3 on the Tulsa Head Injury Screen
• • Any medical condition interfering with the participation in the study as determined by medical screening
• • DSM-5 diagnosis of psychotic disorders, bipolar I disorder, or major depressive disorder with psychosis
• • fMRI contraindications as listed on the MR environment screening form
• • Positive breathalyzer for alcohol
• • Positive urine drug screening, except for cannabis or prescribed benzodiazepines, as indicated in the medical screening
• • Evidence of inability to comply with study procedures based on judgement of the experimenter.