Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients

Launched by UNIVERSITY OF SIENA · May 10, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how effective two different mouthwashes are in improving gum health and reducing bacteria in patients with gingivitis, which is a gum disease that can lead to more serious issues like periodontitis. The two mouthwashes being compared are one with 0.2% chlorhexidine (CHX) and another that combines 0.05% CHX with 0.05% cetylpyridinium chloride (CPC). The study will last for six months and will also check if using these mouthwashes affects blood pressure.

To participate in this trial, you should be between 18 and 75 years old and have signs of gum disease, such as bleeding gums when they are checked by a dentist. You should have at least 20 teeth and limited deep gum pockets. However, if you are allergic to certain medications or are taking specific drugs, you may not be eligible. Participants can expect to use the assigned mouthwash and attend regular check-ups to monitor their gum health and any changes in their blood pressure. This study aims to find out which mouthwash is better for improving gum health and preventing future problems.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Bleeding on probing (BOP) ≥10%,
• • No more than 4 sites with pocket depth (PPD) \>5mm
• • Presence of attachment loss (AL) and radiographic bone loss (RBL)
• • A minimum of 20 teeth
• Exclusion Criteria:
• • Intolerance or allergy to antimicrobials
• • Systemic therapy with anticoagulants/beta-blockers
• • Local/systemic antibiotic therapy 3 months before
• • Inability to understand and sign the written informed consent