A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

Launched by UNIVERSITY OF WASHINGTON · May 7, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new approach to help older patients who have survived serious illnesses in the intensive care unit (ICU). Many of these patients, especially those aged 60 and older, can experience serious cognitive issues, similar to mild Alzheimer's disease, after they leave the hospital. The study aims to see if combining strategies to improve sleep and provide cognitive training can help these patients recover better and reduce the risk of cognitive decline and Alzheimer's disease. The researchers believe that timing these interventions to align with the body’s natural rhythms, known as circadian rhythms, may enhance their effectiveness.

To be eligible for this trial, participants must be at least 60 years old, have spent more than 24 hours in the ICU, and be currently hospitalized at the University of Washington Medical Center. They also need to have been independent in daily activities before their hospitalization. However, individuals with a history of Alzheimer's disease, dementia, certain mental health conditions, or severe impairments might not be able to participate. If enrolled, participants can expect to take part in activities aimed at improving their sleep and cognitive function, which could help them recover more fully after their time in the ICU.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age greater than or equal to 60 years old
• • Current hospitalization at University of Washington Medical Center or Harborview Medical Center
• • Intensive care unit (ICU) length of stay greater than 24 hours
• • Recovery from critical care status to acute care status, and/or discharge out of ICU
• • Fluent in English or Spanish
• • Functional independence on activities of daily living prior to hospitalization (Katz Index = 6)
• Exclusion Criteria:
• • Documented history or suspicion of Alzheimer's disease or dementia, or current prescription of anti-dementia medication
• • Documented history of bipolar disorder or schizophrenia
• • Documented acute stroke or traumatic brain injury
• • Severe vision impairment
• • Severe hearing impairment
• • Severe paralysis or dominant arm paresis
• • Transfer from skilled nursing care facility or inpatient rehabilitation facility