Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting

Launched by PEKING UNIVERSITY FIRST HOSPITAL · May 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a medication called oliceridine to see if it can help reduce nausea and vomiting after laparoscopic colorectal surgery. These symptoms, known as postoperative nausea and vomiting (PONV), are common after surgery and can make recovery slower and more uncomfortable for patients. Oliceridine is a new type of pain relief medicine that works differently from traditional opioids, which often lead to more side effects like nausea. The researchers want to find out if using oliceridine for pain management can help patients feel better and recover more quickly after their surgery.

To be eligible for this study, participants need to be between 18 and 80 years old, scheduled for elective laparoscopic colorectal surgery, and require patient-controlled intravenous pain relief. However, individuals who are pregnant, have certain severe health conditions, or cannot participate due to language barriers or severe dementia will not be included. Those who join the study will receive oliceridine and will be monitored for their recovery, specifically looking at how often they experience nausea and vomiting after their surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged between 18 and 80 years;
• • 2. Scheduled to undergo elective laparoscopic colorectal surgery;
• • 3. Required patient-controlled intravenous analgesia.
• Exclusion Criteria:
• • 1. Pregnancy.
• • 2. Severe heart dysfunction (New York Heart Association functional classification 4), hepatic insufficiency (Child-Pugh grade C), renal insufficiency (serum creatinine of 442 μmol/L or above, or requirement of renal replacement therapy), or Amercian Society of Anesthesiologists classification IV or above.
• • 3. Unable to complete preoperative assessment due to severe dementia or language barrier.
• • 4. Other conditions that are considered unsuitable for study participation.