Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy

Launched by MASONIC CANCER CENTER, UNIVERSITY OF MINNESOTA · May 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying two different methods of managing pain after a surgery called pancreatoduodenectomy, which involves removing part or all of the pancreas and the duodenum (the first part of the small intestine). The trial compares a technique called rectus sheath block, where a long-lasting pain medication called liposomal bupivacaine is injected into the abdomen to help control pain, with a traditional method known as thoracic epidural analgesia (TEA), which uses a catheter placed in the spine to deliver pain relief medication.

To join this study, participants must be adults aged 18 and older who are having this specific surgery at the University of Minnesota. However, individuals with certain conditions that may complicate the procedure, such as bleeding disorders or allergies to local anesthetics, as well as those who have been using high doses of opioids before the surgery, may not be eligible. If you participate, you can expect to receive one of the two pain management methods and will be monitored for how well it helps control your pain after surgery. This trial aims to see if the new approach is just as effective as the traditional one while possibly offering fewer side effects.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients, age 18 and older, undergoing open pancreaticoduodenectomy at the University of Minnesota will be included in the study
• Exclusion Criteria:
• • Patients with contraindication to block placement (coagulopathy, local anesthetic allergy, infection)
• • Patients with chronic opioid use (at least 30 milligram morphine equivalents \[MME\] for 3 or more weeks leading up to surgery)
• • Patients unable to understand the quality of recovery survey intellectual barriers. This will be determined by the primary investigator/attending anesthesiologist's discretion
• • Patient refusal and those who have opted out of research
• • Pregnant patients - will be assessed through review of the medical record