Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies

Launched by IRCCS OSPEDALE SAN RAFFAELE · May 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying rare eye diseases to understand how certain substances in the body, like neurokinin 1 receptor and substance P, may be linked to inflammation and pain in these conditions. The researchers are also looking at other targets related to eye health. To gather information, they will collect samples of blood, tear fluid, and cells from the eye during routine eye exams. This study aims to improve our understanding of these diseases and potentially lead to better treatments.

To participate, individuals must be at least 18 years old and diagnosed with a rare eye disease, or they can be part of a control group without such a diagnosis. However, some people may not be eligible if they are currently pregnant, have an active eye infection, or have had recent eye surgery. Those who join the study will undergo standard eye exams and provide the necessary samples, helping researchers learn more about these conditions. It's important to note that the trial is not yet recruiting participants, so if you’re interested, keep an eye out for updates!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Inclusion Criteria for study group
• • Women and men with age equal or higher than 18 years (patients in reproductive age may be included in the study).
• • Willingness and ability to read and understand the informed consent.
• • Diagnosis (including genotype, if needed) of REDs.
• • Inclusion Criteria for control group
• • Women and men with age equal or higher than 18 years (patients in reproductive age may be included in the study).
• • Willingness and ability to read and understand the informed consent.
• • Non - diagnosis of REDs.
• Exclusion Criteria:
• • Exclusion Criteria for study group
• Patients who meet these criteria will be excluded from participation in the study:
• • Pregnancy, breastfeeding.
• • Active ocular infection.
• • Descemetocele/impending corneal perforation.
• • Recent (less than 3 months) ocular surgery.
• • Recent (less than 1 month) change in topical medications type and frequency.
• • Exclusion Criteria for control group
• Patients who meet these criteria will be excluded from participation in the study:
• • Pregnancy, breastfeeding.
• • Active ocular infection.
• • Descemetocele/impending corneal perforation.
• • Recent (less than 3 months) ocular surgery.
• • Recent (less than 1 month) change in topical medications type and frequency.