The Effects of Different Loading Doses of Dexmedetomidine on The Bispectral Index-Guided Propofol Sedation in Patients Undergoing Advanced Upper Gastrointestinal Endoscopic Procedures: A Randomized Control Study

Launched by THEODOR BILHARZ RESEARCH INSTITUTE · May 13, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of different doses of a medication called dexmedetomidine when combined with propofol, a common sedative, during advanced upper gastrointestinal endoscopic procedures. The goal is to find the best way to use these medications together to keep patients comfortable while minimizing risks, especially since propofol can sometimes cause breathing problems. By testing various doses of dexmedetomidine, researchers hope to discover the ideal balance that enhances sedation safety and effectiveness.

To participate in this trial, you need to be between 18 and 65 years old, and your health should be classified as ASA I or II, meaning you are generally healthy or have mild health issues. You should also have a body mass index (BMI) under 35. Unfortunately, individuals with certain health conditions, such as severe heart problems or allergies to the medications being studied, will not be eligible. If you join the study, you can expect to receive either dexmedetomidine or a placebo (a non-active substance) while being monitored closely during your procedure. Your participation could help improve sedation techniques for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18-65
• • Both sexes
• • ASA I-II
• • BMI \<35
• Exclusion Criteria:
• • Patients' refusal to participate
• • ASA III-IV
• • BMI \> 35
• • Patients who are considered high aspiration risk, e.g., gastric outlet obstruction
• • Allergy to any medications used
• • Diabetics
• • Any patient receiving cardioactive drugs, e.g., Beta blockers, Calcium channel blockers, Inhaled B2 bronchodilators)
• • Patients with Pacemakers or heart rate below 50 beat/min
• • Pregnant women
• • Habitual Drug abusers
• • Patients who had to be intubated during the procedure.