Effect of Repetitive Transcranial Magnetic Stimulation on Neurological Recovery in Patients With Ischaemic Stroke

Launched by THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY · May 10, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether a treatment called repetitive transcranial magnetic stimulation (rTMS) can help patients recover from an ischemic stroke, which occurs when blood flow to the brain is blocked. The researchers want to find out if rTMS can improve movement and function in the arms of patients and if it can change how different parts of the brain connect and work together. Participants will receive either the rTMS treatment or a placebo (sham stimulation) over five days and will be assessed before and after the treatment to see how well they are doing.

To participate in this study, individuals need to be between 18 and 75 years old and have had a stroke confirmed by a brain scan within the last two weeks. They should only have weakness in one arm and be right-handed. Importantly, participants must not have any metal implants, serious medical conditions, or previous brain injuries that could affect their ability to take part in the trial. This trial is a way to explore new treatments for stroke recovery, and it aims to provide valuable insights into how we can help patients regain their abilities after a stroke.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The age range is 18\~75 years old
• • 2. Meet the diagnostic criteria of China Acute Ischaemic Stroke Diagnosis and Treatment Guidelines 2018 and confirmed by head CT or MRI scanning
• • 3. Acute stage of the disease \<14 days and stable condition
• • 4. Stroke patients with only unilateral limb involvement (without bilateral cerebrovascular lesions)
• • 5. Patients with upper limb muscle strength ≥ grade 3, able to perform fNIRS tasks with the patient.
• • 6. Subjects were right-handed
• • 7. Participants give their informed consent and sign an informed consent form
• Exclusion Criteria:
• • 1. Those who have metal implants or any electronic devices in their body
• • 2. Those with previous epilepsy or mental abnormality.
• • 3. Combined with serious heart, liver, lung and other important organ failure
• • 4. Those who have brain haemorrhage or bleeding tendency.
• • 5. Deteriorating condition, new cerebral infarction or secondary cerebral haemorrhage.
• • 6. Patients with history of craniocerebral trauma and craniocerebral surgery.
• • 7. Those with severe cognitive and communication disorders who are unable to cooperate -