Retinal Vessel Leakage in Cerebral Small Vessel Disease

Launched by UNIVERSITY OF EDINBURGH · May 14, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how leakage from blood vessels in the eye, known as retinal vessel leakage, relates to a condition called cerebral small vessel disease. This condition can lead to problems like small strokes and vascular dementia, which affects memory and thinking. Researchers want to find out if people with cerebral small vessel disease experience leakage in their retinal vessels and if the amount of leakage matches the severity of their brain condition. To do this, they will use a special imaging technique called fluorescein angiography, where a fluorescent dye is injected into a vein to help visualize any leakage in the eye's blood vessels.

To participate in this study, individuals must be aged between 65 and 74 and already be part of the Mild Stroke Study 3. They will need to have had a recent MRI of the brain and clear eye vision. Participants will have already undergone various tests related to their cerebral small vessel disease, and this study will help provide additional insights through retinal imaging. It is important to note that certain conditions, like severe eye diseases or other serious medical issues, may make someone ineligible for this study. Overall, this trial aims to gather valuable information that could help improve understanding and treatment of related conditions.

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Eligibility criteria

• Inclusion Criteria:
• • Membership in the Mild Stroke Study 3 cohort
• • Contrast enhanced MRI within 12 months
• • Clear optical media in both eyes, as assessed by study investigator
• • Best corrected visual acuity (near vision) ≥N36
• Exclusion Criteria:
• • Any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension)
• • Previous treatment for retinal leakage (retinal laser, intravitreal anti-VEGF)
• • Recent eye surgery
• • Shallow anterior chambers as assessed by torch test
• • Pregnancy, renal failure
• • Severe dementia
• • Known allergy to fluorescein
• • History of allergy such as food or drug induced urticaria or history of bronchial asthma
• • Any other severe or acute medical or psychiatric conditions
• • Inability to give informed consent