General Anesthesia Vs Local Anesthesia for Endovascular Treatment in Patients with Unruptured Intracranial Aneurysm Using Flow Diverter

Launched by MING LV · May 11, 2024

Keywords

ClinConnect Summary

This clinical trial is comparing two types of anesthesia—general anesthesia (GA) and local anesthesia (LA)—for patients undergoing a specific procedure called flow diverter placement to treat unruptured intracranial aneurysms (UIAs). An intracranial aneurysm is a weak spot in a blood vessel in the brain that can be life-threatening if it bursts. The trial aims to determine which type of anesthesia is safer and more effective for patients during this procedure.

To participate in this study, individuals must be between 18 and 75 years old and have a clearly diagnosed unruptured aneurysm that is less than 15 mm in size. Participants should also be in relatively good health, with a low score on a disability scale. Those who join the trial will receive either GA or LA during their procedure, and the results will help guide future treatment practices for patients with UIAs. It’s also important to note that certain conditions, like severe health issues or allergies to anesthetic drugs, may exclude someone from participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years old and ≤75 years old, gender is not limited;
• • 2. Patients with previously untreated unruptured intracranial aneurysm (UIA) clearly diagnosed by DSA, CTA, or MRA;
• • 3. UIA maximum diameter \<15mm;
• • 4. Baseline mRS score ≤2;
• • 5. Patients voluntarily participated in this study and signed an informed consent form.
• Exclusion Criteria:
• • 1. The aneurysms are located distal to the anterior cerebral artery (including the anterior communicating artery), distal to the M2 segment of the middle cerebral artery, and distal to the basilar artery;
• • 2. Those who are allergic to any components of the anesthetic drugs;
• • 3. Severe symptoms associated with the target aneurysm at the time of diagnosis, with mRS score ≥3;
• • 4. Pregnant and lactating female patients;
• • 5. Patients with severe renal disease resulting in renal insufficiency (glomerular filtration rate \<30ml/(min﹒1.73m2));
• • 6. Patients with metal implants in the body (e.g., cardiac stents, cardiac prosthetic valves, pacemakers, metal joints, steel plates, non-removable metal dentures, etc.);
• • 7. Patients known to suffer from dementia or psychiatric diseases and claustrophobia can not complete the magnetic resonance examination;
• • 8. Patients with other serious diseases combined at the time of diagnosis with an expected survival time of less than 1 year;
• • 9. Patients who are participating in clinical trials of other drugs or devices;
• • 10. Other conditions that, in the judgment of the investigator, exist that are unsuitable for enrollment.