Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

Launched by UNIVERSITY OF MISSOURI-COLUMBIA · May 13, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how aging and menopause affect the body's response to low oxygen levels, particularly how blood vessels widen in women of different ages. Researchers want to understand how certain receptors in the body play a role in this process. The study is specifically focusing on women who are premenopausal, perimenopausal, or postmenopausal, and it aims to recruit participants between the ages of 25 and 66.

To be eligible for this study, women must be healthy and have a body weight that falls within a normal range. However, women who are pregnant, breastfeeding, or have certain health conditions such as diabetes or high blood pressure will not be able to participate. If you join the study, you can expect to undergo various tests to help researchers gather information about your body's response to low oxygen. This trial is important because it could provide insights into how menopause and aging affect women's health, particularly related to heart and blood vessel function.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female assigned at birth
• • Pre, peri- or post-menopausal
• • Healthy weight (BMI ≥18 and ≤30 kg/m2)
• Exclusion Criteria:
• • Male (assigned at birth)
• • Pregnancy, breastfeeding
• • Use of hormone replacement therapies
• • Hysterectomy
• • Body mass index \>30 kg/m2
• • Diagnosed sleep apnea
• • Current smoking/Nicotine/Drug use
• • Nerve/neurologic disease
• • Cardiovascular, hepatic, renal, respiratory disease
• • Blood pressure ≥140/90 mmHg
• • Diabetes, Polycystic ovarian syndrome
• • Communication barriers
• • Prescription medications
• • Malignant cancer