Head-Cancelled Virtual Reality for Ocular Cranial Nerve Palsies

Launched by KEVIN HOUSTON · May 13, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring how eye exercises performed in virtual reality (VR) can help improve eye movement for people with certain conditions that affect their eye muscles, specifically abducens palsy and internuclear ophthalmoplegia. The researchers are comparing two settings: one where the participant's head moves with the VR environment and another where the head is kept still while the eyes move. The goal is to see if the VR exercises can help increase the range of motion of the eyes that are not working as well.

To join the study, participants need to be between the ages of 65 and 74 and have a specific eye condition affecting one eye, with a significant limitation in eye movement. Those who have better eye movement or certain visual problems will not be eligible. Participants should be able to understand and read English and will need to wear a VR headset, so they should not have any issues that would make this difficult. If you qualify, you can expect to engage in VR exercises designed to enhance your eye movement, and the study could contribute valuable information about new treatment options for eye muscle issues.

Gender

ALL

Eligibility criteria

• OCNP Group Inclusion Criteria:
• • Presence of OCNP in one eye with 50% range-of-motion limitation or worse
• • Able to provide informed consent and will be able to fluently read and understand spoken English
• OCNP Group Exclusion Criteria:
• • Presence of bilateral OCNP
• • Range of motion better than 50%
• • Visual acuity worse than 20/100 in either eye
• • Greater than 4-line difference in visual acuity between the eyes,
• • Structural anomalies or sensory sensitivities (e.g. visual motion sensitivity) that would prevent them from wearing or tolerating a VR headset
• • Participants will be excluded if they are unable to participate if inclusion criteria are not met.
• Normal Group Inclusion Criteria:
• • Absence of OCNP or other neurological or neuro-ophthalmic diseases
• • No strabismus
• • Have normal or near-normal vision with glasses or contact lenses.
• • Be able to provide informed consent and will be able to fluently read and understand spoken English
• Normal Group Exclusion Criteria:
• • Visual acuity worse than 20/100 in either eye
• • Greater than 4-line difference in visual acuity between the eyes
• • Structural anomalies or sensory sensitivities (e.g. visual motion sensitivity) that would prevent them from wearing or tolerating a VR headset
• • Known inability to tolerate visual testing of at least 20 minutes continuously.

Trial Officials