LEARNER- Low dosE AspiRiN prEterm tRial (Angola)

Launched by INSTITUTO NACIONAL DE INVESTIGACAO EM SAUDE, ANGOLA · May 12, 2024

Keywords

ClinConnect Summary

The LEARNER trial is a study focused on understanding how safe and effective it is for pregnant women with sickle cell disease to start taking a low dose of aspirin (100 mg) daily. This trial is taking place in two hospitals in Angola and aims to compare the effects of starting aspirin in the first trimester (the first three months of pregnancy) versus the second trimester (the fourth to sixth months). The goal is to see if taking aspirin early in pregnancy can help improve the health of both the mother and the baby.

To participate in this study, women must be at least 15 years old, have sickle cell disease, and be receiving care at one of the designated hospitals. They should also be willing to attend regular check-ups and give their consent to join the study. However, women in the third trimester of pregnancy, those with certain health conditions like HIV or diabetes, or those with allergies to aspirin cannot participate. If eligible, participants can expect to have regular consultations and will monitor the effects of the aspirin on their health throughout the study. This research could provide valuable information for improving care for pregnant women with sickle cell disease.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Pregnant women with Sickle Cell Disease 15 years old and older
• • 2. Attending Maternidade Lucrecia Paim, Hospital Materno Infantil Dr. Manuel Pedro Azancot de Menezes, or any health commodities in the neighboring area of the referred hospitals
• • 3. Willing to attend the regular consultations, and consent to take part in the study.
• Exclusion Criteria:
• • 1. Pregnant women with Sickle Cell Disease in the third trimester (after week 27)
• • 2. HIV infection
• • 3. Diabetes mellitus
• • 4. Chronic hypertension
• • 5. Liver disease measured by laboratory indication being 3 times above the upper limit of normal
• • 6. Sickle nephropathy
• • 7. Multiple pregnancies
• • 8. Hypersensitivity to aspirin
• • 9. History of blood transfusion in the last 3 months
• • 10.Those who did not consent to participate in the study.