Effect of Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity

Launched by JESUÍNA LAMARTINE NOGUEIRA ARAÚJO · May 12, 2024

Keywords

ClinConnect Summary

To obtain the experimental pregabalin gel, a carbopol 940 gel base was used. To prepare the base gel for the formulation, each component was weighed on an analytical balance and, after 24 hours, the components were taken to a mechanical shaker, rotating at 1000 rpm for 10 minutes. 50% triethanolamine was added to adjust the pH to ±6 and complete gel formation. The concentrations of the components of the initial base formula were adjusted to obtain a homogeneous, transparent gel with good consistency. A PG solution (10 mg/ml) was prepared by diluting the drug, which is presented as a white, ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Sensitive teeth with a response ≥ 04 on the visual analog scale (VAS) to tactile and evaporative stimuli;
• • Dentin exposure in anterior and/or posterior teeth, either due to the presence of non-carious cervical lesions and/or gingival recession.
• Exclusion Criteria:
• • Allergic to the active ingredient and/or components of the formulation;
• • Carious lesions and/or dental pulpitis;
• • Recent medication with analgesics or anti-inflammatories;
• • Received desensitizing treatment, orthodontic treatment, or having undergone tooth whitening up to six months prior baseline.
• • Large restorations in sensitive teeth
• • Eating disorders (bulimia, anorexia,...)
• • Periodontal disease (moderate to severe)
• • Bruxism
• • Cracks or fractures in the enamel;
• • Pregnant or breastfeeding women.

Trial Officials