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Search / Trial NCT06417645

Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model

Launched by UNIVERSIDAD DEL DESARROLLO · May 11, 2024

Trial Information

Current as of August 19, 2025

Recruiting

Keywords

Propofol, Eleveld, Bis, Predicted Effect Site Model, Non Lineal Behavior

ClinConnect Summary

This clinical trial is studying how a specific model (Eleveld’s model) can help doctors understand how the drug propofol affects patients during surgery. Propofol is commonly used to help patients relax and lose consciousness while undergoing elective (planned) surgeries. In this study, researchers will give propofol very slowly to healthy patients and monitor how well the model predicts changes in consciousness and brain activity during the procedure. The goal is to see how accurately the model can measure the effects of propofol as patients go in and out of consciousness.

To participate in this trial, you must be a healthy adult aged between 18 and 60 years who is scheduled for elective surgery at the Hospital Base San José Osorno in Chile. Some individuals may not qualify, such as those having emergency surgery, those with certain medical conditions affecting consciousness, or those allergic to propofol. If you join the study, you can expect close monitoring during your surgery and your responses to the medication will be carefully recorded to improve understanding of propofol use in surgical settings.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • ASA I-II patients between 18 and 60 years of age, who undergo elective surgery in the central ward of the Hospital Base San José Osorno, Chile. Consecutive patients from the beginning of the study up to 12 months from the admission of the first patient.
  • Exclusion Criteria:
  • Emergency surgery patient.
  • Patients with dementia, delirium or altered state of consciousness.
  • Full stomach or risk of aspiration.
  • Allergic to propofol.

About Universidad Del Desarrollo

Universidad del Desarrollo (UDD) is a leading academic institution in Chile, renowned for its commitment to advancing healthcare and medical research. With a strong emphasis on innovation and interdisciplinary collaboration, UDD actively engages in clinical trials aimed at enhancing patient outcomes and contributing to the global body of medical knowledge. The university's dedicated research teams leverage state-of-the-art facilities and a robust network of partnerships to conduct rigorous, ethically sound studies across various therapeutic areas, ensuring the highest standards of scientific integrity and patient safety.

Locations

Osorno, , Chile

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported