Trials
Search / Trial NCT06417684

Comparison of Amitriptyline to Lifestyle Modification as Intervention for Vestibular Migraine

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · May 11, 2024

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Trial Information

Current as of March 14, 2025

Enrolling by invitation

Keywords

Vestibular

ClinConnect Summary

1.0 Background

Vestibular migraine (VM) is one of the most common causes of vertigo attacks, affecting 1 - 5% of people. People with vestibular migraine have lower quality of life compared to others and some may experience completely debilitating symptoms. Symptoms include vertigo, nausea, head motion-induced dizziness, unsteadiness, balance problems, and lightheadedness. Most reports of vestibular migraine management have focused on treatment with medications; however, the investigators have shown that intervention with lifestyle modification is also effective.

1.1 Lifestyle Modification...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • English-speaking adults
  • • Diagnosed with Definite Vestibular Migraine
  • • Currently prescribed rescue medication for migraine is acceptable
  • Exclusion Criteria:
  • • Non-English speaking
  • • Diagnosed and undergoing treatment for active Definite Meniere's disease
  • • Already using amitriptyline
  • * Contraindicated for intervention with amitriptyline including:
  • • Patients with Hepatic Impairment
  • • Patients with Renal Impairment
  • • Pregnancy
  • • Breastfeeding
  • • Elderly Patients
  • • Allergy to amitriptyline
  • • Heart attack
  • • Used an MAO inhibitor in the past 14 days
  • • Used an "SSRI" antidepressant in the past 5 weeks
  • • Bipolar disorder (manic-depression) or schizophrenia
  • • Mental illness or psychosis
  • • Stroke
  • • Seizures
  • • Diabetes
  • • Glaucoma
  • • Problems with urination

Trial Officials

Richard A Roberts, PhD

Principal Investigator

Vanderbilt University Medical Center

About Vanderbilt University Medical Center

Vanderbilt University Medical Center (VUMC) is a leading academic medical center located in Nashville, Tennessee, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, VUMC integrates cutting-edge scientific inquiry with patient-centered care, supporting a diverse array of studies aimed at enhancing medical knowledge and improving treatment outcomes. With a robust infrastructure and a multidisciplinary team of experts, VUMC fosters collaboration across various fields, ensuring the highest standards of safety and ethical considerations in its research endeavors. Through its dedication to medical discovery and education, VUMC plays a pivotal role in shaping the future of medicine.

Locations

Nashville, Tennessee, United States

Nashville, Tennessee, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0