Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women

Launched by WOMEN'S HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY · May 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment approach for young women who have early-stage endometrial cancer or endometrial hyperplasia and want to preserve their ability to have children. The researchers want to find out if a specific drug, called the membrane-inhibiting formula, taken with oral progestins, can help clear these conditions more quickly and what side effects might occur. They will also look at how effective this treatment is, any side effects that participants may experience, the chances of the condition coming back, and how long it takes to become pregnant after treatment.

To join the trial, women aged 18 to 45 who have been diagnosed with certain types of early-stage endometrial cancer or hyperplasia can apply. Participants will take the study medication daily and visit the clinic every three months for check-ups and tests. They'll also keep a diary to track their health and examination results. It's important to know that women who have certain health conditions or who do not wish to preserve their fertility will not be eligible for the study.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1.18-45 years old with a strong desire to preserve fertility; 2. pathologically diagnosed with primary grade1 or grade2 endometrioid endometrial carcinoma and hyperplasia 3.no signs of suspicious myometrial invasion by enhanced magnetic resonance imaging (MRI) 4. no signs of suspicious extrauterine metastasis by enhanced computed tomography and CT scan of the Lungs
• Exclusion Criteria:
• • 1.have contraindication for pregnancy. 2.no fertility requiremen 3.have myometrial invasion or extrauterine metastasis 4.pathologically diagnosed with primary grade3 endometrioid endometrial carcinoma or non-endometrioid endometrial carcinoma 5.Any disease or symptom that may affect the implementation of the study or the interpretation of the results