Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · May 15, 2024
Trial Information
Current as of March 13, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the effects of cannabis and cannabinoids—substances found in marijuana—on patients who have just been diagnosed with certain types of cancer, such as breast, colorectal, lung, melanoma, and non-Hodgkin lymphoma. The goal is to understand both the benefits and potential risks of using these substances while patients are receiving their cancer treatments, which may include chemotherapy or other targeted therapies.
To participate, you need to be at least 18 years old and have recently been diagnosed with one of the specified types of cancer, planning to start treatment soon. You should also be comfortable completing surveys in English or Spanish, which can be done online from home or in the clinic. If you choose to join, you’ll share your experiences regarding cannabis use and how it affects your treatment. This trial is currently recruiting participants, and it’s important to note that if you are already involved in another treatment study for managing cancer symptoms, you won't be eligible. Overall, your participation could help provide valuable insights into how cannabis might impact cancer treatment for future patients.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adults aged 18 years or older with one of the following newly diagnosed cancers: breast cancer, colorectal cancer, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer.
- • Planned treatment with systemic chemotherapy (single or multi-agent, includes targeted therapy) and/or immune checkpoint inhibitor therapy (targeting PD-1, PD-L1 or CTLA-4). If unable to engage participant before treatment starts, enrollment is allowed up to the start of Cycle 2 treatment.
- • Participants must be able to comprehend English or Spanish (for survey completion).
- • Participants must have a working email address and be must be willing to complete surveys online. This can be completed at home, in the clinic or other location.
- • Completion of the confidential Self-Reported Screening Survey and receipt of a screening result - eligible for enrollment.
- Optional Sub-study (available at select sites only):
- • Must be willing to participate in both the main study and the sub-study at the Wake Forest University Comprehensive Cancer Center (WF CCC) and Virginia Commonwealth University (VCU).
- • Must be receiving treatment at the WF CCC and VCU.
- • Must be diagnosed with non-small cell lung cancer.
- • Must be receiving paclitaxel as part of their chemotherapy in conjunction with Immune Checkpoint Inhibitor (ICIs) PD-1, PD-L1 or CTLA-4.
- • Must be enrolled and complete baseline survey before cycle 1 begins
- Exclusion Criteria:
- • Currently enrolled in an interventional supportive treatment trial to manage cancer symptoms.
- • Participants with known pregnancy.
- Optional Substudy (available at select sites only):
- • Participants with chronic or ongoing steroid or immunomodulatory agents (i.e., prednisone, dexamethasone, etanercept, infliximab, etc.). The use of glucocorticoids as pre-medications for chemotherapy treatment is allowed.
- • Participants with a history of HIV, hepatitis B or hepatitis C.
Trial Officials
Glenn Lesser, MD
Study Chair
Wake Forest University Health Sciences
About Wake Forest University Health Sciences
Wake Forest University Health Sciences is a leading academic research institution dedicated to advancing healthcare through innovative clinical trials and translational research. With a strong emphasis on multidisciplinary collaboration, the organization leverages its extensive expertise in medical research, patient care, and education to develop and evaluate new therapies and interventions. Committed to improving patient outcomes and public health, Wake Forest University Health Sciences fosters a dynamic environment for scientific inquiry, engaging in a wide range of clinical studies that address pressing health challenges. Through its rigorous methodologies and ethical standards, the institution aims to contribute significantly to the medical field and enhance the quality of life for diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Edina, Minnesota, United States
Saint Paul, Minnesota, United States
Kalamazoo, Michigan, United States
Traverse City, Michigan, United States
Coon Rapids, Minnesota, United States
Urbana, Illinois, United States
Minneapolis, Minnesota, United States
Saint Paul, Minnesota, United States
Shakopee, Minnesota, United States
Willmar, Minnesota, United States
Effingham, Illinois, United States
Wisconsin Rapids, Wisconsin, United States
Springfield, Illinois, United States
Minneapolis, Minnesota, United States
Aurora, Colorado, United States
Saint Cloud, Minnesota, United States
Saint Louis, Missouri, United States
Billings, Montana, United States
Robbinsdale, Minnesota, United States
Saint Louis Park, Minnesota, United States
Saint Louis, Missouri, United States
Green Bay, Wisconsin, United States
Marshfield, Wisconsin, United States
Decatur, Illinois, United States
Ottawa, Illinois, United States
Cedar Rapids, Iowa, United States
Maplewood, Minnesota, United States
Maplewood, Minnesota, United States
Findlay, Ohio, United States
Galesburg, Illinois, United States
Elkton, Maryland, United States
Springfield, Missouri, United States
Billings, Montana, United States
Portland, Oregon, United States
Green Bay, Wisconsin, United States
Oconto Falls, Wisconsin, United States
Rice Lake, Wisconsin, United States
Wausau, Wisconsin, United States
Weston, Wisconsin, United States
Newark, Ohio, United States
Wausau, Wisconsin, United States
New Ulm, Minnesota, United States
Denver, Colorado, United States
Denver, Colorado, United States
Chippewa Falls, Wisconsin, United States
Canton, Illinois, United States
Carthage, Illinois, United States
Eureka, Illinois, United States
Kewanee, Illinois, United States
Macomb, Illinois, United States
Peru, Illinois, United States
Princeton, Illinois, United States
Boise, Idaho, United States
Joplin, Missouri, United States
Greenville, South Carolina, United States
Greenville, South Carolina, United States
Fort Smith, Arkansas, United States
Post Falls, Idaho, United States
Bloomington, Illinois, United States
Pekin, Illinois, United States
Saint Louis, Missouri, United States
Boiling Springs, South Carolina, United States
Easley, South Carolina, United States
Greenville, South Carolina, United States
Greenville, South Carolina, United States
Greer, South Carolina, United States
Seneca, South Carolina, United States
Wisconsin Rapids, Wisconsin, United States
Teaneck, New Jersey, United States
Fairbanks, Alaska, United States
Oklahoma City, Oklahoma, United States
Springfield, Illinois, United States
Belpre, Ohio, United States
Great Falls, Montana, United States
Newark, Delaware, United States
Newark, Delaware, United States
Rehoboth Beach, Delaware, United States
Caldwell, Idaho, United States
Coeur D'alene, Idaho, United States
Flint, Michigan, United States
Anaconda, Montana, United States
Thornton, Colorado, United States
Bardstown, Kentucky, United States
Lexington, Kentucky, United States
Boulder, Colorado, United States
Denver, Colorado, United States
Littleton, Colorado, United States
Lone Tree, Colorado, United States
Centralia, Illinois, United States
Decatur, Illinois, United States
Effingham, Illinois, United States
Mattoon, Illinois, United States
O'fallon, Illinois, United States
Yorkville, Illinois, United States
Sullivan, Missouri, United States
Findlay, Ohio, United States
Norton Shores, Michigan, United States
Henderson, Nevada, United States
Greenville, South Carolina, United States
Eau Claire, Wisconsin, United States
Aurora, Illinois, United States
Port Townsend, Washington, United States
Las Vegas, Nevada, United States
Stevens Point, Wisconsin, United States
Medford, Wisconsin, United States
Centennial, Colorado, United States
Dixon, Illinois, United States
Washington, Illinois, United States
Farmington, Missouri, United States
Burnsville, Minnesota, United States
Bozeman, Montana, United States
Neenah, Wisconsin, United States
New London, Wisconsin, United States
Shawano, Wisconsin, United States
Waupaca, Wisconsin, United States
Missoula, Montana, United States
Oshkosh, Wisconsin, United States
Springfield, Illinois, United States
Antigo, Wisconsin, United States
Sheboygan, Wisconsin, United States
Berlin, Wisconsin, United States
Kalispell, Montana, United States
Wyoming, Michigan, United States
Muskegon, Michigan, United States
Nampa, Idaho, United States
Pontiac, Michigan, United States
Ann Arbor, Michigan, United States
Neillsville, Wisconsin, United States
Danville, Illinois, United States
Rhinelander, Wisconsin, United States
Stevens Point, Wisconsin, United States
Ladysmith, Wisconsin, United States
Minocqua, Wisconsin, United States
Osage Beach, Missouri, United States
Sunset Hills, Missouri, United States
Marysville, Ohio, United States
O'fallon, Illinois, United States
Grand Rapids, Michigan, United States
Escanaba, Michigan, United States
Sandpoint, Idaho, United States
Ontario, Oregon, United States
Winston Salem, North Carolina, United States
Millville, Delaware, United States
Flint, Michigan, United States
Havre, Montana, United States
Mount Vernon, Illinois, United States
Iron Mountain, Michigan, United States
London, Kentucky, United States
Sainte Genevieve, Missouri, United States
Sheboygan, Wisconsin, United States
Sturgeon Bay, Wisconsin, United States
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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