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Search / Trial NCT06418256

Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · May 13, 2024

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Trial Information

Current as of March 14, 2025

Recruiting

Keywords

Spleen Human Splenic Physiology Splenic Clearance Splenic Filtration Mechanisms Perfusion Experiments Role Of The Spleen In The Adaptive Immune Response Genetic Spleen Mechanisms Blood Erythrocytes Leukocytes Lymphocytes Malaria Sickle Cell Disease Hereditary Spherocytosis

ClinConnect Summary

This clinical trial is studying the role of the spleen in various diseases, particularly how it helps manage abnormal blood cells. The spleen is important for our immune system, which helps our body fight infections and diseases. Researchers want to learn more about how the spleen functions, especially in patients who are having surgery to remove the spleen (splenectomy) for different reasons. They will also explore if certain treatments can improve how the spleen recognizes and responds to blood cells.

To participate in the trial, you need to be an adult who is scheduled for a splenectomy. The study is open to anyone, regardless of their gender, and is currently looking for volunteers. If you join, you can expect to be part of investigations that could lead to a better understanding of how the spleen works and how it can be affected by certain diseases, which may help improve treatments in the future.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Adult patients
  • • Patient requiring left splenopancreectomy or planned splenectomy regardless of the method or indication
  • Exclusion Criteria:
  • • - The patient notified his doctor of his refusal to recover his spleen and blood volume

Trial Officials

Pierre Buffet, MD, PhD

Principal Investigator

Assistance Publique - Hôpitaux de Paris

About Assistance Publique Hôpitaux De Paris

Assistance Publique - Hôpitaux de Paris (AP-HP) is a leading public hospital system in France, renowned for its commitment to healthcare excellence and innovative medical research. As a prominent clinical trial sponsor, AP-HP plays a pivotal role in advancing medical knowledge and improving patient care through rigorous scientific investigations across a wide range of therapeutic areas. With a focus on collaboration and interdisciplinary approaches, AP-HP leverages its extensive network of hospitals and expert clinicians to facilitate high-quality clinical trials that adhere to the highest ethical and regulatory standards, ultimately aiming to translate research findings into tangible health benefits for diverse patient populations.

Locations

Clichy, , France

Paris, , France

Paris, , France

Paris, , France

Paris, , France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0