The Correlation of Intracranial Artery Calcification and Outcomes of Mechanical Thrombectomy

Launched by ZHUJIANG HOSPITAL · May 15, 2024

Keywords

ClinConnect Summary

The CAIS-MT trial is studying how the buildup of calcium in the brain's arteries, known as intracranial artery calcification (IAC), affects the outcomes for patients undergoing a specific treatment called endovascular treatment (EVT) after having an acute ischemic stroke. This type of stroke happens when a blood vessel in the brain gets blocked, and EVT is a procedure used to remove that blockage. The goal of the trial is to see if there is a relationship between the level of calcium buildup and how well patients recover after the procedure.

To participate in this study, you need to be an adult over 18 years old who has symptoms of an acute stroke and has a blockage in certain brain arteries, confirmed by imaging tests. Importantly, you should not have had a stroke more than 24 hours before seeking treatment, and certain health conditions that could complicate the study must be ruled out. If you decide to join, you will need to provide informed consent, and the research team will follow up with you to gather information about your recovery and health outcomes. This trial is currently recruiting participants, and it aims to provide valuable insights into improving stroke treatment and recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or non-pregnant women with acute stroke symptoms aged over 18 years.
• • Occlusion of the intracranial internal carotid artery, the middle cerebral artery, the anterior cerebral artery, the posterior cerebral artery, basilar artery and intracranial vertebral artery confirmed by CT, MR angiography, or digital subtraction angiography.
• • No absolute contraindication to iodinated contrast media.
• • Planned treatment with EVT by clinical care team.
• • Informed consent obtained from patients or their legal representatives.
• • Willing to be followed up as required by the clinical study protocol.
• Exclusion Criteria:
• • Acute ischemic stroke occurs over 24 hours of time last known well.
• • Neurologic deficits caused by diagnoses other than ischemic stroke, such as intracerebral hemorrhage, subarachnoid hemorrhage, or intracranial tumors.
• • With other underlying factors leading to IAC, such as hyperthyroidism, end-stage renal disease, long-term oral intake of vitamin K antagonist(Warfarin), chronic vitamin D deficiency or overdose, persistent hypomagnesemia, persistent hypercalcemia, persistent hyperphosphatemia and high oral calcium intake.
• • Lack of non-contract CT images on admission and significant artifacts in CT images preventing IAC measurement.
• • Severe renal insufficiency (estimated glomerular filtration rate \< 30ml/min or serum creatinine \> 220μmol/L (2.5mg/dl)).
• • Previous cerebrovascular intervention treatment or craniotomy.