Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw
Launched by UNIVERSITY HOSPITAL, TOULOUSE · May 16, 2024
Trial Information
Current as of February 12, 2025
Not yet recruiting
Keywords
ClinConnect Summary
Resulting in bone loss, infection, pain or discomfort, the presence of MRONJ decreases the quality of life of patients. There isn't any consensus about the treatment modalities for MRONJ, nor about its main goals. Traditionally, therapeutics only aimed to control and prevent the progression of the disease, but recent studies suggest that a whole resolution can currently be expected, especially from surgical therapies. These, when indicated, are not only intended for the removal of the pathological tissue, but above all for an hermetic mucosal healing, preventing secondary infection of the u...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • MRONJ requiring surgical treatment according to AAOMS criteria (stage 2 or 3; failure of first-line treatments; sequestration of a necrotic bone block), the resection of which needs general anesthesia;
- • Affiliates or beneficiaries of a social security scheme.
- • Having given free and informed written consent.
- Exclusion Criteria:
- • Presence of a maxillo-mandibular neoplastic lesion;
- • Presence of several MRONJ lesions;
- • History of cervico-facial radiotherapy;
- • Contraindication to general anesthesia;
- • Reduced life expectancy (estimated at less than 6 months).
Trial Officials
Claire VILLEPINTE, MD
Principal Investigator
University Hospital, Toulouse
About University Hospital, Toulouse
The University Hospital of Toulouse is a leading academic medical center dedicated to advancing healthcare through innovative research and clinical trials. With a strong emphasis on patient-centered care, the hospital integrates cutting-edge scientific inquiry with comprehensive clinical services. Its multidisciplinary team of healthcare professionals collaborates with renowned researchers to facilitate pioneering studies across various medical fields, aiming to enhance treatment options and improve patient outcomes. As a prominent institution in the region, the University Hospital of Toulouse is committed to fostering an environment of excellence in both education and research within the healthcare community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Toulouse, , France
Bordeaux, , France
Bordeaux, , France
Limoges, , France
Montpellier, , France
Paris, , France
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0