Trials
Search / Trial NCT06419010

Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw

Launched by UNIVERSITY HOSPITAL, TOULOUSE · May 16, 2024

Trial Information

Current as of February 12, 2025

Not yet recruiting

Keywords

Therapeutics Surgical Autologous Platelet Concentrates Platelet Rich Fibrin Prf

ClinConnect Summary

Resulting in bone loss, infection, pain or discomfort, the presence of MRONJ decreases the quality of life of patients. There isn't any consensus about the treatment modalities for MRONJ, nor about its main goals. Traditionally, therapeutics only aimed to control and prevent the progression of the disease, but recent studies suggest that a whole resolution can currently be expected, especially from surgical therapies. These, when indicated, are not only intended for the removal of the pathological tissue, but above all for an hermetic mucosal healing, preventing secondary infection of the u...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • MRONJ requiring surgical treatment according to AAOMS criteria (stage 2 or 3; failure of first-line treatments; sequestration of a necrotic bone block), the resection of which needs general anesthesia;
  • Affiliates or beneficiaries of a social security scheme.
  • Having given free and informed written consent.
  • Exclusion Criteria:
  • Presence of a maxillo-mandibular neoplastic lesion;
  • Presence of several MRONJ lesions;
  • History of cervico-facial radiotherapy;
  • Contraindication to general anesthesia;
  • Reduced life expectancy (estimated at less than 6 months).

Trial Officials

Claire VILLEPINTE, MD

Principal Investigator

University Hospital, Toulouse

About University Hospital, Toulouse

The University Hospital of Toulouse is a leading academic medical center dedicated to advancing healthcare through innovative research and clinical trials. With a strong emphasis on patient-centered care, the hospital integrates cutting-edge scientific inquiry with comprehensive clinical services. Its multidisciplinary team of healthcare professionals collaborates with renowned researchers to facilitate pioneering studies across various medical fields, aiming to enhance treatment options and improve patient outcomes. As a prominent institution in the region, the University Hospital of Toulouse is committed to fostering an environment of excellence in both education and research within the healthcare community.

Locations

Toulouse, , France

Bordeaux, , France

Bordeaux, , France

Limoges, , France

Montpellier, , France

Paris, , France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0