Multimodal Rehabilitation on Gastric Adenocarcinoma Patients Following Radical D2 Gastrectomy
Launched by ZHEJIANG CANCER HOSPITAL · May 13, 2024
Trial Information
Current as of February 19, 2025
Not yet recruiting
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Clinical diagnosis of Alzheimer's Disease
- • Must be able to swallow tablets
- • Age 18 to 75 years old
- • Patients with gastric adenocarcinoma (including gastroesophageal junction adenocarcinoma) confirmed by histopathology to be in pathological stage II/III (based on the eighth edition of the AJCC Cancer Staging Manual)
- • The patient underwent D2 radical resection within 3-6 weeks before randomization; and met the R0 resection criteria
- • The patient can undergo postoperative adjuvant chemotherapy after being selected into the randomization group, and the regimen is SOX/XELOX
- • Have not received previous anti-tumor treatment (including systemic chemotherapy and local radiotherapy), except for initial gastrectomy of the primary lesion
- • ECOG status score 0 or 1, with physical conditions to participate in sports training、Have sufficient bone marrow reserve function, ANC ≥1.5×109/L, platelet count ≥75×109/L, Hb ≥90 g/L before enrollment, and no bleeding tendency
- • Liver function test: alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) are all ≤ 2.5×ULN; serum bilirubin ≤ 1.5×ULN. For patients known to have Gilbert's disease: Serum bilirubin level ≤ 3xULN
- • Renal function test: Serum creatinine (Cr) ≤ 1.5 x ULN or creatinine clearance \> 50 ml/min (calculated according to Cockroft-Gault)
- • No mental illness, speech disorder or consciousness disorder, have certain understanding, communication and reading abilities, and be able to complete the questionnaire independently or with the assistance of the researcher
- • During the study, at least one source of social support (family member or friend) can monitor the safety and compliance of the intervention program
- • Can understand the situation of this study, and the patient and/or legal representative voluntarily agree to participate in this trial and sign the informed consent form.
- Exclusion Criteria:
- • Receive neoadjuvant chemotherapy or radiotherapy before surgery;
- • Participate in other clinical trials related to health behavior within 3 months before the trial;
- • Treated with any other study drugs or participated in another clinical trial with therapeutic intent within 28 days before enrollment;
- • Uncontrolled serious medical illness that the investigator believes will affect the subject's acceptance of the rehabilitation program, such as combined serious medical illness, including severe heart disease (such as New York Heart Association (NYHA) Class II or worse congestion heart failure), cerebrovascular disease, uncontrolled diabetes, uncontrolled hypertension, uncontrolled infection, etc.;
- • Lack of ability to participate in sports training (such as: disability, paralysis of lower limbs, etc.); not suitable for participating in sports training, such as those suffering from skeletal muscle diseases, fractures within 6 months; suffering from exercise contraindications (angina pectoris, within 6 months) Myocardial infarction, congestive heart failure, chronic obstructive pulmonary disease, planned hip or knee replacement, use of a walker or wheelchair, recent stroke with hemiplegia, etc.);
- • Those who are receiving other forms of nutritional intervention; those who refuse to use oral nutritional preparations;
- • There is uncontrolled mental illness;
- • Known active HIV, HBV and HCV infection;
- • Patients with malignant tumors other than gastric cancer (except current gastric cancer) within the past 5 years; are eligible if they meet all the following criteria: treatment of malignant tumors with the purpose of cure, such as fully treated cervical cancer in situ, non-melanoma skin Cancer, localized prostate cancer after radical resection (PSA ≤ 10ng/ml); at the same time, no signs of recurrence or metastasis were found based on imaging follow-up results and any disease-specific tumor markers;
- • Those with difficulty swallowing, complete or incomplete gastrointestinal obstruction, active gastrointestinal bleeding, or perforation;
- • Pregnant or lactating female patients, or subjects of childbearing age who refuse to take contraceptive measures;
- • Patients judged by the researcher to be unfit to participate in this study.
Trial Officials
Jieer Jieer, Dr
Principal Investigator
Zhejiang Cancer Hospital
About Zhejiang Cancer Hospital
Zhejiang Cancer Hospital is a leading medical institution in China, dedicated to advancing cancer research, treatment, and patient care. As a prominent clinical trial sponsor, the hospital focuses on innovative therapies and evidence-based practices to improve outcomes for cancer patients. With a multidisciplinary team of experienced oncologists and researchers, Zhejiang Cancer Hospital is committed to fostering collaboration and leveraging cutting-edge technology in its clinical trials. The institution aims to contribute significantly to the global understanding of cancer and enhance therapeutic options through rigorous research and development initiatives.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hangzhou, Zhejiang, China
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0