Passive Stretching in Peripheral Arterial Disease Patients

Launched by UNIVERSITY OF WISCONSIN, LA CROSSE · May 14, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how passive stretching of the calf muscles can help patients with Peripheral Arterial Disease (PAD), a condition that causes pain in the legs during walking due to poor blood flow. The researchers believe that this stretching may improve blood flow and walking ability by increasing levels of a helpful molecule called nitric oxide. They will also explore whether combining the stretching with a special diet rich in nitrates could further enhance these benefits. Over 12 weeks, participants will undergo stretching exercises while the study monitors changes in inflammation and blood vessel health.

To join the trial, participants must have a specific measure of blood flow known as the ankle-brachial index of 0.90 or less and must have been stable in their condition for at least three months. However, those who have been regularly exercising or in rehabilitation for the past three months, or have certain serious conditions like critical limb ischemia or heart failure, cannot participate. This study is important as it seeks to find new ways to help people with PAD improve their ability to walk and lead more active lives.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ankle-brachial index of 0.90 or less Stable condition for at least 3 months
• Exclusion Criteria:
• • Habitual exercise or cardiovascular rehabilitation program during the past 3 months Critical limb ischemia, amputation, or leg pain at rest Major surgery or lower extremity revascularization in the last 3 months Heart Failure Kidney disease Beet allergy Crohn's Current smoker