Incidence and Impact of ICU-acquired Diaphragm Weakness

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · May 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a condition called diaphragmatic dysfunction, which affects the diaphragm—the main muscle used for breathing—especially in patients who have spent time in the Intensive Care Unit (ICU). Research shows that many ICU survivors experience weakness in this muscle, which can lead to longer hospital stays and a higher risk of complications after leaving the ICU. The trial aims to find out if having this weakness when discharged from the ICU affects a patient’s health in the following 90 days.

To participate in this study, you must be at least 18 years old and have required respiratory support for at least 48 hours, but you should have been taken off that support within the last day. If you or your trusted family member are interested and agree to participate, you will help researchers understand how diaphragmatic weakness impacts recovery. However, people with pre-existing breathing issues or certain medical conditions will not be eligible for this trial. Your involvement could help improve care for future ICU patients!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years
• • 2. Invasive or non-invasive respiratory support (ventilation, high-flow oxygen therapy, whatever the reason) for at least 48 hours.
• • 3. Weaning from respiratory support (invasive or not) within the last 24 hours.
• • 4. Patient (or trusted person/relative) informed and not opposed to the study.
• Exclusion Criteria:
• • 1. Known pre-existing diaphragmatic dysfunction (phrenic lesion, neuromuscular disease, etc.)
• • 2. Patients with tracheostomy
• • 3. Non-communicating patients
• • 4. Patients deprived of liberty by court or administrative order, or under legal protection (guardianship, curators).