Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
Launched by KING'S COLLEGE HOSPITAL NHS TRUST · May 14, 2024
Trial Information
Current as of February 19, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This study is looking at babies born 2- 6 weeks early who have breathing problems soon after birth. Some babies need to go onto a breathing machine (ventilator) or require 'non-invasive' breathing support. Either a machine delivers warmed, moist oxygen + air through short tubes in the nose (humidified high flow nasal cannula, HHFNC) or a machine delivers oxygen and air via a small mask which fits over the nose (continuous positive airway pressure, CPAP). Mechanical ventilation via a ventilator, although life-saving, can cause problems such as infection and lung injury and, therefore, whenev...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Infants born at 34+0 to 38+6 weeks of gestation, requiring resuscitation at birth, but who achieve regular spontaneous breathing and have a heart rate over 100 beats per minute while receiving non-invasive support.
- • Infants enrolled in the Surfon trial, born at 34+0 to 38+6 weeks of gestation, who are less than or equal to 24 hours old and exhibit signs of respiratory distress, defined as an FiO2 greater or equal to 0.30 but less than 0.45 needed to maintain an SpO2 greater than or equal to 92% or a clinically significant work of breathing regardless of the FiO2 and a clinical decision to provide non-invasive respiratory support.
- Exclusion Criteria:
- • Infants requiring intubation at birth
- • Infants with severe congenital anomalies.
Trial Officials
Theodore Dassios, PHD
Principal Investigator
King's College London
About King's College Hospital Nhs Trust
King's College Hospital NHS Trust is a leading healthcare institution in the United Kingdom, renowned for its commitment to providing high-quality patient care and advancing medical research. With a strong emphasis on clinical excellence, the Trust supports a wide range of clinical trials across various specialties, leveraging its state-of-the-art facilities and a multidisciplinary team of healthcare professionals. By fostering innovation and collaboration, King's College Hospital NHS Trust aims to enhance treatment options and improve outcomes for patients, while contributing to the global body of medical knowledge through rigorous scientific investigation.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0