Trials
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Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants

Launched by KING'S COLLEGE HOSPITAL NHS TRUST · May 14, 2024

Trial Information

Current as of February 19, 2025

Not yet recruiting

Keywords

ClinConnect Summary

This study is looking at babies born 2- 6 weeks early who have breathing problems soon after birth. Some babies need to go onto a breathing machine (ventilator) or require 'non-invasive' breathing support. Either a machine delivers warmed, moist oxygen + air through short tubes in the nose (humidified high flow nasal cannula, HHFNC) or a machine delivers oxygen and air via a small mask which fits over the nose (continuous positive airway pressure, CPAP). Mechanical ventilation via a ventilator, although life-saving, can cause problems such as infection and lung injury and, therefore, whenev...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Infants born at 34+0 to 38+6 weeks of gestation, requiring resuscitation at birth, but who achieve regular spontaneous breathing and have a heart rate over 100 beats per minute while receiving non-invasive support.
  • Infants enrolled in the Surfon trial, born at 34+0 to 38+6 weeks of gestation, who are less than or equal to 24 hours old and exhibit signs of respiratory distress, defined as an FiO2 greater or equal to 0.30 but less than 0.45 needed to maintain an SpO2 greater than or equal to 92% or a clinically significant work of breathing regardless of the FiO2 and a clinical decision to provide non-invasive respiratory support.
  • Exclusion Criteria:
  • Infants requiring intubation at birth
  • Infants with severe congenital anomalies.

Trial Officials

Theodore Dassios, PHD

Principal Investigator

King's College London

About King's College Hospital Nhs Trust

King's College Hospital NHS Trust is a leading healthcare institution in the United Kingdom, renowned for its commitment to providing high-quality patient care and advancing medical research. With a strong emphasis on clinical excellence, the Trust supports a wide range of clinical trials across various specialties, leveraging its state-of-the-art facilities and a multidisciplinary team of healthcare professionals. By fostering innovation and collaboration, King's College Hospital NHS Trust aims to enhance treatment options and improve outcomes for patients, while contributing to the global body of medical knowledge through rigorous scientific investigation.

Locations

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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