Investigating the Role of Adjuvant Proton Beam Therapy in Patients With Parotid Carcinoma

Launched by THE CHRISTIE NHS FOUNDATION TRUST · May 14, 2024

Keywords

ClinConnect Summary

Malignant parotid tumours are uncommon. Whilst 85% of salivary gland tumours originate in the parotid gland, only 20-25% of these are malignant, representing only 3-6% of head and neck cancers. This is about 650 patients/year in the UK.

Standard treatment for local disease is with surgical resection followed by adjuvant radiotherapy for patients with high-risk features. Local control and 5-year survival rates are good, at \>70% and \>80% respectively, but radiotherapy is associated with considerable toxicity. More than 70% of patients receiving photon therapy experience significant dysgeus...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. ≥ 18 years old.
• • 2. Histologically confirmed primary malignant tumours of parotid gland.
• • 3. Requiring post-operative radiotherapy to the parotid bed, with a dose equivalent of at least 60 Gray (Gy) in 2 Gy / fraction.
• • 4. Treatment delivered with radical intent.
• • 5. All patients must be suitable to attend regular follow-up, audiograms, toxicity monitoring, and be available for long term follow-up.
• • 6. Willingness to comply with the protocol, including travel to the proton centre for Intensity Modulated Proton Therapy (IMPT) treatment.
• • 7. Written informed consent.
• Exclusion Criteria:
• • 1. Previous radiotherapy to the head and neck region;
• • 2. Parotid tumours requiring primary radiation or those with gross residual disease;
• • 3. Metastases from squamous cell carcinoma of the head and neck to the parotid gland;
• • 4. Benign tumours requiring post operative radiotherapy;
• • 5. Previous or concurrent illness, which in the investigators opinion would interfere with either completion of therapy or follow-up;
• • 6. Patients requiring or receiving neoadjuvant, concomitant or planned adjuvant chemotherapy.
• • 7. Patients who are eligible for PBT under routine commissioning

Trial Officials