Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery

Launched by QIANFOSHAN HOSPITAL · May 17, 2024

Keywords

ClinConnect Summary

Neurosurgery has a high incidence of postoperative pulmonary complications, increasing patient costs and affecting patient prognosis. Neurosurgery often requires hyperventilation to reduce intracranial pressure, so methods to reduce postoperative pulmonary complications such as small tidal volumes cannot be used routinely, and larger tidal volumes often result in injury to pulmonary endothelial cells, which leads to increased permeability of the pulmonary microvasculature, resulting in mechanically ventilated lung injury. Of course surgical injuries and mechanical ventilation can also cause...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients who need craniotomy treatment due to intracranial tumors;
• • 2. age 18-75 years old;
• • 3. American Society of Anesthesiologists classification: 1\~3;
• • 4. Patients and their families agree to participate in the study and sign the informed consent form.
• Exclusion Criteria:
• • 1. Patients with severe pulmonary infection or respiratory failure prior to surgery;
• • 2. Patients with previous history of neurological or psychiatric diseases;
• • 3. Patients with cardiac, hepatic and renal insufficiency;
• • 4. patients who are receiving parenteral nutrition;
• • 5. pregnant patients;
• • 6. Patients ruled out by medication instructions;
• • 7. Patients who require emergency surgery;
• • 8. patients with combination of other malignant tumors;
• • 9. patients who have participated in other clinical studies of drugs within 3 months.

Trial Officials