A Prospective Study: Smart Phone Application for Measure Serum Bilirubin Through Sclera Images

Launched by AIR FORCE MILITARY MEDICAL UNIVERSITY, CHINA · May 15, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new smartphone application that helps measure bilirubin levels, which can indicate jaundice, by taking pictures of the white part of the eye (the sclera). Jaundice can occur when there’s too much bilirubin in the blood, often due to liver problems. The study aims to see how accurately the app can predict bilirubin levels compared to traditional tests. It will take place over three months and is currently looking for participants who are at least 14 years old and visiting the Gastroenterology Department of Xijing Hospital for liver function tests.

To be eligible, participants should have certain conditions like pancreatitis or liver issues, but must not have any eye diseases that could change the color of the sclera or have recently eaten a lot of foods like carrots or oranges that can affect the eye's color. Participants will be asked to cooperate during the eye examination, which involves following simple instructions to help capture clear images. Importantly, there are no known safety risks associated with this trial, so it could be a safe way to explore a new method for monitoring jaundice.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 14 years or older. Subjects who are visiting the Gastroenterology Department of Xijing Hospital and will undergo liver function tests on the same day. The disease spectrum of the subjects mainly includes pancreatitis, pancreatic tumors, hepatobiliary stones, biliary tumors, and colonic polyps.
• Exclusion Criteria:
• • Subjects with diseases that may cause abnormal changes in scleral color, such as glaucoma, Wilson's disease, pterygium, or scleritis.
• • Subjects who have recently consumed a large amount of carotenoid-rich foods (such as oranges or carrots).
• • Subjects who are unable to provide informed consent.
• Elimination Criteria:
• • Subjects with incomplete scleral exposure due to limited eye movement or excessive tension during external eye examination.
• • Subjects who are unable to understand the instructions for eye rotation during scleral examination or are unable to cooperate due to reasons such as poor hearing.