Effect of Pentoxifylline Versus Probiotic on Preterm Neonates With Necrotizing Enterocolitis

Launched by TANTA UNIVERSITY · May 14, 2024

Keywords

ClinConnect Summary

This randomized clinical trial includes 75 preterm infants who met the inclusion criteria for stage I and stage II NEC. Patients are allocated randomly into three groups (each included 25 neonates); group I (traditional therapy group) received antibiotics according to culture and sensitivity results, group II (pentoxifylline group) received antibiotics and IV pentoxifylline at a dose of 30 mg/ Kg given over 6 hours daily until discharge from the unit, and group III (probiotics group) received antibiotics and probiotics sachets supplementation in a dose of 100 mg mixed with 10 ml sterile wat...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male and female preterm neonates less than 37 weeks gestational age
• • Suffering from necrotizing enterocolitis (NEC), according to Modified Bell's system which was first proposed by Bell et al., 1978 as stage I (suspected), II (proven) .
• • Diagnosis of NEC depends on; history, physical examination, laboratory and radiographic findings .
• • Signs and symptoms of NEC (at least three or more ), including; unstable temperature, apnea, increased residual milk in stomach, mid abdominal distension, vomiting coffee-like substances, bloody stool
• • Laboratory findings including; thrombocytopenia, hypernatremia, metabolic acidosis, neutropenia and leukocytosis.
• • Anterior posterior abdominal radiograph is used for diagnosis in which pneomatosis intestinalis in stage II NEC
• Exclusion Criteria:
• • Term and post term neonates
• • Neonates with congenital infections
• • Neonates with major congenital anomalies
• • Neonates with stage III NEC

Trial Officials