An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures

Launched by UNIVERSITY OF SANTIAGO DE COMPOSTELA · May 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether taking an oral antibiotic called doxycycline can help prevent infections in the bloodstream after dental procedures, particularly for patients who may be at risk of developing a serious infection known as endocarditis. Endocarditis can occur when bacteria enter the bloodstream and affect the heart, so finding effective ways to prevent it is very important, especially after dental extractions.

To be eligible for this trial, participants should be between 18 and 75 years old and must have at least 10 teeth, as well as a need for a dental extraction under general anesthesia. The trial is open to all genders and does not consider the severity of dental disease. However, people who have recently taken antibiotics, have certain allergies, or have specific medical conditions may not be able to participate. If you join the trial, you can expect to receive doxycycline and be monitored for any potential effects. This study may help improve guidelines for preventing infections after dental work in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subjects must have at least 10 teeth.
• • Subjects must have the need for a dental extraction under general anesthesia (for behavioral reasons).
• • Subjects will be recruited regardless of the extent and severity of their dental and/or periodontal disease.
• Exclusion Criteria:
• • Age under 18 years
• • Body weight under 40 kg
• • Receipt of antibiotics in the previous 3 months
• • Routine use of oral antiseptics
• • A history of allergy or intolerance to doxycycline
• • A history of allergy or intolerance to cindamycin
• • Any type of congenital or acquired immunodeficiency
• • Any known risk factor for bacterial endocarditis
• • Any known risk factor for prolonged bleeding