Sleep Apnea and Cognition in Older Adults

Launched by SUNNYBROOK HEALTH SCIENCES CENTRE · May 15, 2024

Keywords

ClinConnect Summary

This clinical trial, called "Sleep Apnea and Cognition in Older Adults," aims to understand how different aspects of sleep might affect thinking and memory in older adults. Researchers are particularly interested in how certain breathing patterns during sleep are related to cognitive performance. To find this out, participants will wear a device called the ANNE Vital Sign System for 24 hours while also completing various memory and thinking tests.

Eligible participants are men and women aged 55 to 85 who can understand English and have at least eight years of education. They should not have serious cognitive issues like dementia and must be able to cooperate during the study. If you take part, you can expect to wear the monitoring device for a day and complete some cognitive assessments. This study is currently looking for volunteers, and your participation could help improve our understanding of how sleep impacts brain function in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Sufficient knowledge of English to understand and provide informed consent
• • 2. Competent to provide consent
• • 3. Aged 55-85, Male and Female
• • 4. ≥ 8 years of education
• • 5. Capable of cooperating for the duration of the study procedures and assessments
• • 6. No frank cognitive impairment or dementia
• • 7. Sufficient (corrected) vision to participate in cognitive testing
• • 8. Sufficient (corrected) hearing to participate in cognitive testing
• Exclusion Criteria:
• • 1. Cannot read and comprehend English language instructions
• • 2. Major cardio- or cerebro-vascular event (heart attack, stroke, significant white matter changes)
• • 3. Unstable diseases (e.g., pulmonary, endocrine disorder)
• • 4. Active malignancy or infectious diseases
• • 5. History of significant learning disability
• • 6. Major psychiatric/neurologic/degenerative disorder, including a diagnosis of mild cognitive impairment or dementia
• • 7. History of significant head trauma or recurrent concussions requiring hospitalization followed by persistent neurologic defaults or known structural brain abnormalities
• • 8. Pain or sleep disorder that could interfere with cognitive testing
• • 9. Major medical concerns that might interfere with cognitive testing
• • 10. Recent history of substance/drug abuse
• • 11. Known nickel allergy
• • 12. Known cardiac implantable device
• • 13. Known arrhythmias
• • 14. Outside the included age range
• • 15. Pregnant or breast feeding
• • 16. Otherwise unable to use the ANNE sensors; for example, finger amputations.

Trial Officials